Growth differentiation factor: Difference between revisions

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<StructureSection load='3evs' size='350' side='right' caption='Structure of growth differentiation factor GDF-5 (green) complex with bone morphogenetic receptor (pink) (PDB entry [[3evs]])' scene=''>
<StructureSection load='3evs' size='350' side='right' caption='Structure of growth differentiation factor GDF-5 (green and aqua) complex with bone morphogenetic receptor (pink and olive) (PDB entry [[3evs]])' scene=''>
      
      
'''Growth differentiation factor''' (GDF) are proteins which function in development.<br />
'''Growth differentiation factor''' (GDF) are proteins which function in development.<br />
*'''GDF-2''' or '''bone morphogenetic protein 9''' maintains the response of cholinergic neurons to acetylcholine.<br />
*'''GDF-2''' or '''bone morphogenetic protein 9''' maintains the response of cholinergic neurons to acetylcholine.<br />
*'''GDF-5''' is expressed in the central nervous system and is involved in the development of joints and skeleton.<br />
*'''GDF-5''' is expressed in the central nervous system and is involved in the development of joints and skeleton<ref>PMID:23432680</ref>.<br />
*'''GDF-8''' or '''myostatin''', controls the growth of muscle tissue.  For more details see [[Group:MUZIC:Myostatin]].
*'''GDF-8''' or '''myostatin''', controls the growth of muscle tissue<ref>PMID:10610713</ref>.  For more details see [[Group:MUZIC:Myostatin]].<br />
</StructureSection>
*'''GDF-11''' or '''bone morphogenetic protein 11''' is a circulating factor that reverses age-related cardiac hypertrophy<ref>PMID:23663781</ref>.
 
*'''GDF-15''' or '''placental bone morphogenetic protein''' protects the hart from ischmia and reperfusion injury<ref>PMID:16484622</ref>.
See also [[Growth factors]] and [[Bone morphogenetic protein]].
==3D structures of growth differentiation factor==
==3D structures of growth differentiation factor==
[[Growth differentiation factor 3D STRUCTURES]]


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
</StructureSection>
{{#tree:id=OrganizedByTopic|openlevels=0|
 
*GDF-2
 
**[[1zkz]], [[4mpl]] – hGDF residues 320-493 – human  <br />
**[[4fao]] – hGDF residues 320-493 + serine/threonine-protein kinase receptor + activin receptor<br />
**[[4ycg]], [[4yci]] – mGDF residues 23-318 + hGDF residues 320-493 - mouse<br />
 
*GDF-5
 
**[[2bhk]], [[1waq]] – hGDF  <br />
**[[3evs]] – hGDF + bone morphogenetic receptor  <br />
**[[3qb4]] – hGDF (mutant) + bone morphogenetic receptor  <br />
 
*GDF-8


**[[3hh2]] – mGDF + follistatin  <br />
== References ==
**[[3sek]] – mGDF + follistatin-related protein  <br />
<references/>
}}
[[Category:Topic Page]]
[[Category:Topic Page]]
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