4z6y: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry~~ 4z6y is ~~ON HOLD~~

==Structure of the TBC1D7-TSC1 complex==

~~Authors~~: ~~Gai~~, Z., Wu, G.

== Structural highlights ==

<table><tr><td colspan='2'>[[4z6y]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z6Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Z6Y FirstGlance]. <br>

~~Description~~:

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.81Å</td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4z6y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z6y OCA], [https://pdbe.org/4z6y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4z6y RCSB], [https://www.ebi.ac.uk/pdbsum/4z6y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4z6y ProSAT]</span></td></tr>

[[Category: ~~Wu, G~~]]

</table>

[[Category: Gai, Z]]

== Function ==

[https://www.uniprot.org/uniprot/TBCD7_HUMAN TBCD7_HUMAN] Component of the TSC-TBC complex, that contains TBC1D7 in addition to the TSC1-TSC2 complex and consists of the functional complex possessing GTPase-activating protein (GAP) activity toward RHEB in response to alterations in specific cellular growth conditions. The small GTPase RHEB is a direct activator of the protein kinase activity of mTORC1 and the TSC-TBC complex acts as a negative regulator of mTORC1 signaling cascade by acting as a GAP for RHEB. Participates in the proper sensing of growth factors and glucose, but not amino acids, by mTORC1. It is unclear whether TBC1D7 acts as a GTPase-activating protein and additional studies are required to answer this question.<ref>PMID:22795129</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Gai Z]]

[[Category: Wu G]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 4z6y is ON HOLD
+==Structure of the TBC1D7-TSC1 complex==
+<StructureSection load='4z6y' size='340' side='right'caption='[[4z6y]], [[Resolution|resolution]] 2.81&Aring;' scene=''>
-Authors: Gai, Z., Wu, G.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4z6y]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z6Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Z6Y FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.81&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4z6y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z6y OCA], [https://pdbe.org/4z6y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4z6y RCSB], [https://www.ebi.ac.uk/pdbsum/4z6y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4z6y ProSAT]</span></td></tr>
-[[Category: Wu, G]]
+</table>
-[[Category: Gai, Z]]
+== Function ==
+[https://www.uniprot.org/uniprot/TBCD7_HUMAN TBCD7_HUMAN] Component of the TSC-TBC complex, that contains TBC1D7 in addition to the TSC1-TSC2 complex and consists of the functional complex possessing GTPase-activating protein (GAP) activity toward RHEB in response to alterations in specific cellular growth conditions. The small GTPase RHEB is a direct activator of the protein kinase activity of mTORC1 and the TSC-TBC complex acts as a negative regulator of mTORC1 signaling cascade by acting as a GAP for RHEB. Participates in the proper sensing of growth factors and glucose, but not amino acids, by mTORC1. It is unclear whether TBC1D7 acts as a GTPase-activating protein and additional studies are required to answer this question.<ref>PMID:22795129</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Gai Z]]
+[[Category: Wu G]]