4z7f: Difference between revisions
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New page: '''Unreleased structure''' The entry 4z7f is ON HOLD Authors: Zhao qin, Wang chengcheng, Wang chengyuan, Zhang peng Description: Category: Unreleased Structures [[Category: Zhao Q... |
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==Crystal structure of FolT bound with folic acid== | |||
<StructureSection load='4z7f' size='340' side='right'caption='[[4z7f]], [[Resolution|resolution]] 3.19Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4z7f]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterococcus_faecalis_V583 Enterococcus faecalis V583]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z7F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Z7F FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.194Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FOL:FOLIC+ACID'>FOL</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4z7f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z7f OCA], [https://pdbe.org/4z7f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4z7f RCSB], [https://www.ebi.ac.uk/pdbsum/4z7f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4z7f ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/Q837A3_ENTFA Q837A3_ENTFA] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Energy-coupling factor (ECF) transporters are a new family of ABC transporters that consist of four subunits, two cytoplasmic ATPases EcfA and EcfA' and two transmembrane proteins namely EcfS for substrate-specific binding and EcfT for energy coupling. Here, we report the 3.2-A resolution crystal structure of the EcfS protein of a folate ECF transporter from Enterococcus faecalis-EfFolT, a close homologue of FolT from Lactobacillus brevis-LbFolT. Structural and biochemical analyses reveal the residues constituting the folate-binding pocket and determining the substrate-binding specificity. Structural comparison of the folate-bound EfFolT with the folate-free LbFolT contained in the holotransporter complex discloses significant conformational change at the L1 loop, and reveals a gating mechanism of ECF transporters in which the L1 loop of EcfS acts as a gate in the substrate binding and release. | |||
Structures of FolT in substrate-bound and substrate-released conformations reveal a gating mechanism for ECF transporters.,Zhao Q, Wang C, Wang C, Guo H, Bao Z, Zhang M, Zhang P Nat Commun. 2015 Jul 22;6:7661. doi: 10.1038/ncomms8661. PMID:26198469<ref>PMID:26198469</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
[[Category: | <div class="pdbe-citations 4z7f" style="background-color:#fffaf0;"></div> | ||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Enterococcus faecalis V583]] | |||
[[Category: Large Structures]] | |||
[[Category: Wang CC]] | |||
[[Category: Wang CY]] | |||
[[Category: Zhang P]] | |||
[[Category: Zhao Q]] | |||
Latest revision as of 15:42, 8 November 2023
Crystal structure of FolT bound with folic acid
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