4z7m: Difference between revisions
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The | ==Novel Inhibitors of Bacterial Methionine Aminopeptidase with Broad-Spectrum Biochemical Activity== | ||
<StructureSection load='4z7m' size='340' side='right'caption='[[4z7m]], [[Resolution|resolution]] 1.43Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4z7m]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z7M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Z7M FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.43Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4L9:N~2~-[(3,5-DIFLUOROPHENYL)ACETYL]-N-[(3S,7R)-1-METHYL-2-OXO-7-PHENYL-2,3,4,7-TETRAHYDRO-1H-AZEPIN-3-YL]-L-ALANINAMIDE'>4L9</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4z7m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z7m OCA], [https://pdbe.org/4z7m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4z7m RCSB], [https://www.ebi.ac.uk/pdbsum/4z7m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4z7m ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/MAP1_ECOLI MAP1_ECOLI] Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.[HAMAP-Rule:MF_01974]<ref>PMID:20521764</ref> <ref>PMID:3027045</ref> | |||
==See Also== | |||
*[[Aminopeptidase 3D structures|Aminopeptidase 3D structures]] | |||
== References == | |||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Escherichia coli]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Albert R]] | ||
[[Category: | [[Category: Fisher SF]] | ||
[[Category: Rose | [[Category: Fleming PR]] | ||
[[Category: | [[Category: Lahiri SD]] | ||
[[Category: McKinney DC]] | |||
[[Category: Morningstar M]] | |||
[[Category: Rose JA]] | |||
[[Category: Shapiro AB]] | |||
Latest revision as of 12:15, 6 March 2024
Novel Inhibitors of Bacterial Methionine Aminopeptidase with Broad-Spectrum Biochemical Activity
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