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==Human PFKFB3 in complex with an indole inhibitor 6==
==Human PFKFB3 in complex with an indole inhibitor 6==
<StructureSection load='5ak0' size='340' side='right' caption='[[5ak0]], [[Resolution|resolution]] 2.03&Aring;' scene=''>
<StructureSection load='5ak0' size='340' side='right'caption='[[5ak0]], [[Resolution|resolution]] 2.03&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5ak0]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AK0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AK0 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5ak0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AK0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AK0 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8V1:(2S)-N-[4-[1-METHYL-3-(1-METHYLPYRAZOL-4-YL)INDOL-5-YL]OXYPHENYL]PYRROLIDINE-2-CARBOXAMIDE'>8V1</scene>, <scene name='pdbligand=F6P:FRUCTOSE-6-PHOSPHATE'>F6P</scene>, <scene name='pdbligand=PHS:PHOSPHONIC+ACID'>PHS</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.03&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5ajv|5ajv]], [[5ajw|5ajw]], [[5ajx|5ajx]], [[5ajy|5ajy]], [[5ajz|5ajz]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8V1:(2S)-N-[4-[1-METHYL-3-(1-METHYLPYRAZOL-4-YL)INDOL-5-YL]OXYPHENYL]PYRROLIDINE-2-CARBOXAMIDE'>8V1</scene>, <scene name='pdbligand=F6P:FRUCTOSE-6-PHOSPHATE'>F6P</scene>, <scene name='pdbligand=PHS:PHOSPHONIC+ACID'>PHS</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ak0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ak0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5ak0 RCSB], [http://www.ebi.ac.uk/pdbsum/5ak0 PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ak0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ak0 OCA], [https://pdbe.org/5ak0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ak0 RCSB], [https://www.ebi.ac.uk/pdbsum/5ak0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ak0 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/F263_HUMAN F263_HUMAN]] Synthesis and degradation of fructose 2,6-bisphosphate.  
[https://www.uniprot.org/uniprot/F263_HUMAN F263_HUMAN] Synthesis and degradation of fructose 2,6-bisphosphate.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 5ak0" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Boyd, S]]
[[Category: Homo sapiens]]
[[Category: Brookfield, J L]]
[[Category: Large Structures]]
[[Category: Critchlow, S E]]
[[Category: Boyd S]]
[[Category: Cumming, I A]]
[[Category: Brookfield JL]]
[[Category: Curtis, N J]]
[[Category: Critchlow SE]]
[[Category: Debreczeni, J E]]
[[Category: Cumming IA]]
[[Category: Degorce, S L]]
[[Category: Curtis NJ]]
[[Category: Donald, C]]
[[Category: Debreczeni JE]]
[[Category: Evans, N J]]
[[Category: Degorce SL]]
[[Category: Groombridge, S]]
[[Category: Donald C]]
[[Category: Hopcroft, P]]
[[Category: Evans NJ]]
[[Category: Jones, N P]]
[[Category: Groombridge S]]
[[Category: Kettle, J G]]
[[Category: Hopcroft P]]
[[Category: Lamont, S]]
[[Category: Jones NP]]
[[Category: Lewis, H J]]
[[Category: Kettle JG]]
[[Category: MacFaull, P]]
[[Category: Lamont S]]
[[Category: McLoughlin, S B]]
[[Category: Lewis HJ]]
[[Category: Rigoreau, L J.M]]
[[Category: MacFaull P]]
[[Category: Smith, J M]]
[[Category: McLoughlin SB]]
[[Category: St-Gallay, S]]
[[Category: Rigoreau LJM]]
[[Category: Stock, J K]]
[[Category: Smith JM]]
[[Category: Wheatley, E R]]
[[Category: St-Gallay S]]
[[Category: Wingfield, J]]
[[Category: Stock JK]]
[[Category: Winter, J]]
[[Category: Wheatley ER]]
[[Category: Transferase]]
[[Category: Wingfield J]]
[[Category: Winter J]]

Latest revision as of 11:41, 9 May 2024

Human PFKFB3 in complex with an indole inhibitor 6

5ak0, resolution 2.03Å

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