2rv8: Difference between revisions
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New page: '''Unreleased structure''' The entry 2rv8 is ON HOLD Authors: Macdonald, R., Sarkar, D., Amer, B.R., Clubb, R.T. Description: Solution Structure of the PhoP DNA-Binding Domain from Myc... |
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The | ==Solution Structure of the PhoP DNA-Binding Domain from Mycobacterium tuberculosis== | ||
<StructureSection load='2rv8' size='340' side='right'caption='[[2rv8]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2rv8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_CAS/NITR204 Mycobacterium tuberculosis CAS/NITR204]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RV8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RV8 FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rv8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rv8 OCA], [https://pdbe.org/2rv8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rv8 RCSB], [https://www.ebi.ac.uk/pdbsum/2rv8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rv8 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/R4MFJ2_MYCTX R4MFJ2_MYCTX] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Tuberculosis caused by Mycobacterium tuberculosis is a leading cause of death world-wide. The PhoP protein is required for virulence and is part of the PhoPR two-component system that regulates gene expression. The NMR-derived solution structure of the PhoP C-terminal DNA-binding domain is reported. Residues 150 to 246 form a structured domain that contains a winged helix-turn-helix motif. We provide evidence that the transactivation loop postulated to contact RNA polymerase is partially disordered in solution, and that the polypeptide that connects the DNA-binding domain to the regulatory domain is unstructured. | |||
Solution structure of the PhoP DNA-binding domain from Mycobacterium tuberculosis.,Macdonald R, Sarkar D, Amer BR, Clubb RT J Biomol NMR. 2015 Sep;63(1):111-7. doi: 10.1007/s10858-015-9965-0. Epub 2015 Jul , 25. PMID:26209027<ref>PMID:26209027</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
[[Category: Amer | <div class="pdbe-citations 2rv8" style="background-color:#fffaf0;"></div> | ||
[[Category: Clubb | == References == | ||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Mycobacterium tuberculosis CAS/NITR204]] | |||
[[Category: Amer BR]] | |||
[[Category: Clubb RT]] | |||
[[Category: Macdonald R]] | |||
[[Category: Sarkar D]] | |||
Latest revision as of 10:05, 14 June 2023
Solution Structure of the PhoP DNA-Binding Domain from Mycobacterium tuberculosis
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