2vkt: Difference between revisions

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[[Image:2vkt.jpg|left|200px]]


{{Structure
==HUMAN CTP SYNTHETASE 2 - GLUTAMINASE DOMAIN==
|PDB= 2vkt |SIZE=350|CAPTION= <scene name='initialview01'>2vkt</scene>, resolution 2.50&Aring;
<StructureSection load='2vkt' size='340' side='right'caption='[[2vkt]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND=  
<table><tr><td colspan='2'>[[2vkt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VKT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VKT FirstGlance]. <br>
|ACTIVITY= [http://en.wikipedia.org/wiki/CTP_synthase CTP synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.2 6.3.4.2]  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
|GENE=  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vkt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vkt OCA], [https://pdbe.org/2vkt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vkt RCSB], [https://www.ebi.ac.uk/pdbsum/2vkt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vkt ProSAT]</span></td></tr>
}}
</table>
 
== Function ==
'''HUMAN CTP SYNTHETASE 2- GLUTAMINASE DOMAIN'''
[https://www.uniprot.org/uniprot/PYRG2_HUMAN PYRG2_HUMAN] Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides.<ref>PMID:10899599</ref> <ref>PMID:16179339</ref>
 
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
==About this Structure==
Check<jmol>
2VKT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VKT OCA].  
  <jmolCheckbox>
[[Category: CTP synthase]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vk/2vkt_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vkt ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C H.]]
[[Category: Arrowsmith CH]]
[[Category: Berg, S Van Den.]]
[[Category: Berglund H]]
[[Category: Berglund, H.]]
[[Category: Busam RD]]
[[Category: Busam, R D.]]
[[Category: Collins R]]
[[Category: Collins, R.]]
[[Category: Dahlgren LG]]
[[Category: Dahlgren, L G.]]
[[Category: Edwards AM]]
[[Category: Edwards, A M.]]
[[Category: Flodin S]]
[[Category: Flodin, S.]]
[[Category: Flores A]]
[[Category: Flores, A.]]
[[Category: Graslund S]]
[[Category: Graslund, S.]]
[[Category: Hammarstrom M]]
[[Category: Hammarstrom, M.]]
[[Category: Herman MD]]
[[Category: Herman, M D.]]
[[Category: Johansson I]]
[[Category: Johansson, I.]]
[[Category: Kallas A]]
[[Category: Kallas, A.]]
[[Category: Karlberg T]]
[[Category: Karlberg, T.]]
[[Category: Kotenyova T]]
[[Category: Kotenyova, T.]]
[[Category: Lehtio L]]
[[Category: Lehtio, L.]]
[[Category: Moche M]]
[[Category: Moche, M.]]
[[Category: Nilsson ME]]
[[Category: Nilsson, M E.]]
[[Category: Nordlund P]]
[[Category: Nordlund, P.]]
[[Category: Nyman T]]
[[Category: Nyman, T.]]
[[Category: Persson C]]
[[Category: Persson, C.]]
[[Category: Sagemark J]]
[[Category: Sagemark, J.]]
[[Category: Svensson L]]
[[Category: Sgc, Structural Genomics Consortium.]]
[[Category: Thorsell AG]]
[[Category: Svensson, L.]]
[[Category: Tresaugues L]]
[[Category: Thorsell, A G.]]
[[Category: Weigelt J]]
[[Category: Tresaugues, L.]]
[[Category: Welin M]]
[[Category: Weigelt, J.]]
[[Category: Van den Berg S]]
[[Category: Welin, M.]]
[[Category: ctp synthtetase]]
[[Category: ctps2]]
[[Category: glutaminase domain]]
[[Category: glutamine amidotransferase]]
[[Category: ligase]]
[[Category: nucleotide metabolism]]
[[Category: phosphorylation]]
[[Category: pyrimidine biosynthesis]]
[[Category: sgc]]
[[Category: structural genomics consortium]]
 
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Retrieved from "https://proteopedia.org/2vkt"