4zgp: Difference between revisions
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New page: '''Unreleased structure''' The entry 4zgp is ON HOLD Authors: Panvert, M., Dubiez, E., Arnold, L., Perez, J., Seufert, W., Mechulam, Y., Schmitt, E. Description: [[Category: Unrelease... |
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==Structure of Cdc123 from Schizosaccharomyces pombe== | |||
<StructureSection load='4zgp' size='340' side='right'caption='[[4zgp]], [[Resolution|resolution]] 1.85Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4zgp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZGP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZGP FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zgp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zgp OCA], [https://pdbe.org/4zgp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zgp RCSB], [https://www.ebi.ac.uk/pdbsum/4zgp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zgp ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/CD123_SCHPO CD123_SCHPO] Regulates the cell cycle in a nutrient dependent manner. | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Eukaryotic initiation factor 2 (eIF2), a heterotrimeric guanosine triphosphatase, has a central role in protein biosynthesis by supplying methionylated initiator tRNA to the ribosomal translation initiation complex and by serving as a target for translational control in response to stress. Recent work identified a novel step indispensable for eIF2 function: assembly of eIF2 from its three subunits by the cell proliferation protein Cdc123. We report the first crystal structure of a Cdc123 representative, that from Schizosaccharomyces pombe, both isolated and bound to domain III of Saccharomyces cerevisiae eIF2gamma. The structures show that Cdc123 resembles enzymes of the ATP-grasp family. Indeed, Cdc123 binds ATP-Mg(2+), and conserved residues contacting ATP-Mg(2+) are essential for Cdc123 to support eIF2 assembly and cell viability. A docking of eIF2alphagamma onto Cdc123, combined with genetic and biochemical experiments, allows us to propose a model explaining how Cdc123 participates in the biogenesis of eIF2 through facilitating assembly of eIF2gamma to eIF2alpha. | |||
Cdc123, a Cell Cycle Regulator Needed for eIF2 Assembly, Is an ATP-Grasp Protein with Unique Features.,Panvert M, Dubiez E, Arnold L, Perez J, Mechulam Y, Seufert W, Schmitt E Structure. 2015 Sep 1;23(9):1596-608. doi: 10.1016/j.str.2015.06.014. Epub 2015, Jul 23. PMID:26211610<ref>PMID:26211610</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
[[Category: | <div class="pdbe-citations 4zgp" style="background-color:#fffaf0;"></div> | ||
[[Category: | == References == | ||
[[Category: Mechulam | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Seufert | [[Category: Schizosaccharomyces pombe]] | ||
[[Category: Arnold L]] | |||
[[Category: Dubiez E]] | |||
[[Category: Mechulam Y]] | |||
[[Category: Panvert M]] | |||
[[Category: Perez J]] | |||
[[Category: Schmitt E]] | |||
[[Category: Seufert W]] | |||
Latest revision as of 11:00, 10 January 2024
Structure of Cdc123 from Schizosaccharomyces pombe
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