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[[Image:2voj.jpg|left|200px]]


{{Structure
==Ternary complex of M. tuberculosis Rv2780 with NAD and pyruvate==
|PDB= 2voj |SIZE=350|CAPTION= <scene name='initialview01'>2voj</scene>, resolution 2.60&Aring;
<StructureSection load='2voj' size='340' side='right'caption='[[2voj]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
|SITE= <scene name='pdbsite=AC1:Binding+Site+For+Residue+Nad+A+500'>AC1</scene>, <scene name='pdbsite=AC2:Binding+Site+For+Residue+2op+A+501'>AC2</scene>, <scene name='pdbsite=AC3:Binding+Site+For+Residue+Nad+C+500'>AC3</scene>, <scene name='pdbsite=AC4:Binding+Site+For+Residue+2op+C+501'>AC4</scene>, <scene name='pdbsite=AC5:Binding+Site+For+Residue+Nad+E+500'>AC5</scene> and <scene name='pdbsite=AC6:Binding+Site+For+Residue+2op+E+501'>AC6</scene>
== Structural highlights ==
|LIGAND= <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene> and <scene name='pdbligand=2OP:(2S)-2-HYDROXYPROPANOIC ACID'>2OP</scene>
<table><tr><td colspan='2'>[[2voj]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VOJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VOJ FirstGlance]. <br>
|ACTIVITY= [http://en.wikipedia.org/wiki/Alanine_dehydrogenase Alanine dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.1.1 1.4.1.1]  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
|GENE=  
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2OP:(2S)-2-HYDROXYPROPANOIC+ACID'>2OP</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2voj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2voj OCA], [https://pdbe.org/2voj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2voj RCSB], [https://www.ebi.ac.uk/pdbsum/2voj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2voj ProSAT]</span></td></tr>
 
</table>
'''TERNARY COMPLEX OF M. TUBERCULOSIS RV2780 WITH NAD AND PYRUVATE'''
== Function ==
 
[https://www.uniprot.org/uniprot/DHA_MYCTU DHA_MYCTU] Catalyzes the reversible reductive amination of pyruvate to L-alanine. However, since the physiological environment of M.tuberculosis has a neutral pH, it can be assumed that the enzyme catalyzes exclusively the formation of L-alanine. May play a role in cell wall synthesis as L-alanine is an important constituent of the peptidoglycan layer.<ref>PMID:10527947</ref>
 
== Evolutionary Conservation ==
==About this Structure==
[[Image:Consurf_key_small.gif|200px|right]]
2VOJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VOJ OCA].  
Check<jmol>
[[Category: Alanine dehydrogenase]]
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vo/2voj_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2voj ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Single protein]]
[[Category: Ramachandran R]]
[[Category: Ramachandran, R.]]
[[Category: Tripathi SM]]
[[Category: Tripathi, S M.]]
[[Category: 2OP]]
[[Category: NAD]]
[[Category: alanine dehydrogenase]]
[[Category: nad]]
[[Category: oxidoreductase]]
[[Category: pyruvate]]
[[Category: rv2780]]
[[Category: secreted]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:47:56 2008''
Retrieved from "https://proteopedia.org/2voj"