4r0c: Difference between revisions

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==Crystal structure of the Alcanivorax borkumensis YdaH transporter reveals an unusual topology==
==Crystal structure of the Alcanivorax borkumensis YdaH transporter reveals an unusual topology==
<StructureSection load='4r0c' size='340' side='right' caption='[[4r0c]], [[Resolution|resolution]] 2.96&Aring;' scene=''>
<StructureSection load='4r0c' size='340' side='right'caption='[[4r0c]], [[Resolution|resolution]] 2.96&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4r0c]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R0C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4R0C FirstGlance]. <br>
<table><tr><td colspan='2'>[[4r0c]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Alcanivorax_borkumensis_SK2 Alcanivorax borkumensis SK2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R0C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4R0C FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=LMT:DODECYL-BETA-D-MALTOSIDE'>LMT</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.963&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4r0c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r0c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4r0c RCSB], [http://www.ebi.ac.uk/pdbsum/4r0c PDBsum]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=LMT:DODECYL-BETA-D-MALTOSIDE'>LMT</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4r0c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r0c OCA], [https://pdbe.org/4r0c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4r0c RCSB], [https://www.ebi.ac.uk/pdbsum/4r0c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4r0c ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Function ==
== Publication Abstract from PubMed ==
[https://www.uniprot.org/uniprot/Q0VR69_ALCBS Q0VR69_ALCBS]
The potential of the folic acid biosynthesis pathway as a target for the development of antibiotics has been clinically validated. However, many pathogens have developed resistance to these antibiotics, prompting a re-evaluation of potential drug targets within the pathway. The ydaH gene of Alcanivorax borkumensis encodes an integral membrane protein of the AbgT family of transporters for which no structural information was available. Here we report the crystal structure of A. borkumensis YdaH, revealing a dimeric molecule with an architecture distinct from other families of transporters. YdaH is a bowl-shaped dimer with a solvent-filled basin extending from the cytoplasm to halfway across the membrane bilayer. Each subunit of the transporter contains nine transmembrane helices and two hairpins that suggest a plausible pathway for substrate transport. Further analyses also suggest that YdaH could act as an antibiotic efflux pump and mediate bacterial resistance to sulfonamide antimetabolite drugs.
 
Crystal structure of the Alcanivorax borkumensis YdaH transporter reveals an unusual topology.,Bolla JR, Su CC, Delmar JA, Radhakrishnan A, Kumar N, Chou TH, Long F, Rajashankar KR, Yu EW Nat Commun. 2015 Apr 20;6:6874. doi: 10.1038/ncomms7874. PMID:25892120<ref>PMID:25892120</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bolla, J R]]
[[Category: Alcanivorax borkumensis SK2]]
[[Category: Su, C C]]
[[Category: Large Structures]]
[[Category: Yu, E W]]
[[Category: Bolla JR]]
[[Category: Membrane protein]]
[[Category: Su C-C]]
[[Category: Transmembrane protein]]
[[Category: Yu EW]]
Retrieved from "https://proteopedia.org/4r0c"