4zja: Difference between revisions
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New page: '''Unreleased structure''' The entry 4zja is ON HOLD Authors: Mani, N., Suguna, K. Description: Category: Unreleased Structures Category: Mani, N Category: Suguna, K |
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==Small heat shock protein AgsA from Salmonella typhimurium: C-terminal truncated construct== | |||
<StructureSection load='4zja' size='340' side='right'caption='[[4zja]], [[Resolution|resolution]] 4.10Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4zja]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZJA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZJA FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4.101Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zja FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zja OCA], [https://pdbe.org/4zja PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zja RCSB], [https://www.ebi.ac.uk/pdbsum/4zja PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zja ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/D1MC98_SALTM D1MC98_SALTM] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Small heat shock proteins are ubiquitous molecular chaperones that form the first line of defence against the detrimental effects of cellular stress. Under conditions of stress they undergo drastic conformational rearrangements in order to bind to misfolded substrate proteins and prevent cellular protein aggregation. Owing to the dynamic nature of small heat shock protein oligomers, elucidating the structural basis of chaperone action and oligomerization still remains a challenge. In order to understand the organization of sHSP oligomers, we have determined crystal structures of a small heat shock protein from Salmonella typhimurium in a dimeric form and two higher oligomeric forms: an 18-mer and a 24-mer. Though the core dimer structure is conserved in all the forms, structural heterogeneity arises due to variation in the terminal regions. | |||
Multiple oligomeric structures of a bacterial small heat shock protein.,Mani N, Bhandari S, Moreno R, Hu L, Prasad BV, Suguna K Sci Rep. 2016 Apr 7;6:24019. doi: 10.1038/srep24019. PMID:27053150<ref>PMID:27053150</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
[[Category: Mani | <div class="pdbe-citations 4zja" style="background-color:#fffaf0;"></div> | ||
[[Category: Suguna | == References == | ||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Salmonella enterica subsp. enterica serovar Typhimurium]] | |||
[[Category: Mani N]] | |||
[[Category: Suguna K]] | |||
Latest revision as of 15:45, 8 November 2023
Small heat shock protein AgsA from Salmonella typhimurium: C-terminal truncated construct
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