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==Humanized Roco4 bound to LRRK2-In1==
==Humanized Roco4 bound to LRRK2-In1==
<StructureSection load='4yzm' size='340' side='right' caption='[[4yzm]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
<StructureSection load='4yzm' size='340' side='right'caption='[[4yzm]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4yzm]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YZM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YZM FirstGlance]. <br>
<table><tr><td colspan='2'>[[4yzm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Dictyostelium_discoideum Dictyostelium discoideum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YZM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YZM FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4K4:2-[(2-METHOXY-4-{[4-(4-METHYLPIPERAZIN-1-YL)PIPERIDIN-1-YL]CARBONYL}PHENYL)AMINO]-5,11-DIMETHYL-5,11-DIHYDRO-6H-PYRIMIDO[4,5-B][1,4]BENZODIAZEPIN-6-ONE'>4K4</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4K4:2-[(2-METHOXY-4-{[4-(4-METHYLPIPERAZIN-1-YL)PIPERIDIN-1-YL]CARBONYL}PHENYL)AMINO]-5,11-DIMETHYL-5,11-DIHYDRO-6H-PYRIMIDO[4,5-B][1,4]BENZODIAZEPIN-6-ONE'>4K4</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yzm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yzm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4yzm RCSB], [http://www.ebi.ac.uk/pdbsum/4yzm PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4yzm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yzm OCA], [https://pdbe.org/4yzm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4yzm RCSB], [https://www.ebi.ac.uk/pdbsum/4yzm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4yzm ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ROCO4_DICDI ROCO4_DICDI]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 4yzm" style="background-color:#fffaf0;"></div>
==See Also==
*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Dictyostelium discoideum]]
[[Category: Alessi, D R]]
[[Category: Large Structures]]
[[Category: Gilsbach, B K]]
[[Category: Alessi DR]]
[[Category: Ito, G]]
[[Category: Gilsbach BK]]
[[Category: Kortholt, A]]
[[Category: Ito G]]
[[Category: Messias, A C]]
[[Category: Kortholt A]]
[[Category: Sattler, M]]
[[Category: Messias AC]]
[[Category: Wittinghofer, A]]
[[Category: Sattler M]]
[[Category: Inhibitor]]
[[Category: Wittinghofer A]]
[[Category: Kinase]]
[[Category: Lrrk2]]
[[Category: Roco-protein]]
[[Category: Transferase]]

Latest revision as of 10:56, 10 January 2024

Humanized Roco4 bound to LRRK2-In1

4yzm, resolution 3.00Å

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