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[[Image:2yy2.gif|left|200px]]


{{Structure
==Crystal structure of the human Phosphodiesterase 9A catalytic domain complexed with IBMX==
|PDB= 2yy2 |SIZE=350|CAPTION= <scene name='initialview01'>2yy2</scene>, resolution 2.80&Aring;
<StructureSection load='2yy2' size='340' side='right'caption='[[2yy2]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene> and <scene name='pdbligand=IBM:3-ISOBUTYL-1-METHYLXANTHINE'>IBM</scene>
<table><tr><td colspan='2'>[[2yy2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YY2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YY2 FirstGlance]. <br>
|ACTIVITY= [http://en.wikipedia.org/wiki/3',5'-cyclic-GMP_phosphodiesterase 3',5'-cyclic-GMP phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.35 3.1.4.35]  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
|GENE=  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yy2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yy2 OCA], [https://pdbe.org/2yy2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yy2 RCSB], [https://www.ebi.ac.uk/pdbsum/2yy2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yy2 ProSAT]</span></td></tr>
}}
</table>
== Function ==
[https://www.uniprot.org/uniprot/PDE9A_HUMAN PDE9A_HUMAN] Hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes.<ref>PMID:18757755</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yy/2yy2_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2yy2 ConSurf].
<div style="clear:both"></div>


'''Crystal structure of the human Phosphodiesterase 9A catalytic domain complexed with IBMX'''
==See Also==
 
*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
 
== References ==
==About this Structure==
<references/>
2YY2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YY2 OCA].
__TOC__
[[Category: 3',5'-cyclic-GMP phosphodiesterase]]
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Handa, N.]]
[[Category: Handa N]]
[[Category: Kotera, J.]]
[[Category: Kotera J]]
[[Category: Omori, K.]]
[[Category: Omori K]]
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
[[Category: Shirouzu M]]
[[Category: Shirouzu, M.]]
[[Category: Terada T]]
[[Category: Terada, T.]]
[[Category: Yokoyama S]]
[[Category: Yokoyama, S.]]
[[Category: IBM]]
[[Category: MG]]
[[Category: ZN]]
[[Category: catalytic domain]]
[[Category: hydrolase]]
[[Category: national project on protein structural and functional analyse]]
[[Category: nppsfa]]
[[Category: phosphodiesterase]]
[[Category: riken structural genomics/proteomics initiative]]
[[Category: rsgi]]
[[Category: structural genomic]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:50:14 2008''

Latest revision as of 10:41, 30 April 2025

Crystal structure of the human Phosphodiesterase 9A catalytic domain complexed with IBMX

2yy2, resolution 2.80Å

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