Plasminogen: Difference between revisions

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{{STRUCTURE_1qrz|  PDB=1qrz  | SIZE=400| SCENE= |right|CAPTION=Human plasmin catalytic domain tetramer, [[1qrz]] }}
<StructureSection load='' size='350' side='right' caption='Human glycosylated plasminogen complex with acetate, bicarbonate, K+ (purple) and Cl- (green) ions (PDB entry [[4dur]])' scene='46/465445/Cv/1'>
== Function ==
'''Plasmin''' (PLN) is a serine protease which is involved in degradation of fibrin clots.  PLN is released as the zymogen '''plasminogen''' (PLG) which is converted to the active PLN by a variety of enzymes.  PLN cleavage produces angiostatin.


'''Plasmin''' (PLN) is a serine protease which is involved in degradation of fibrin clots.  PLN is released as the zymogen '''plasminogen''' (PLG) which is converted to the active PLN by a variety of enzymes.  PLN cleavage produces angiostatin. PLN domains are: N-terminal, C-terminal serine protease catalytic domain and 5 kringle domains of ca. 80 residues.  The kringle domain folds into a large loop containing 3 disulfide bonds.  The kringle domain is important in protein-protein interaction with blood coagulation factors.
*'''Microplasmin''' induces posterior vitreous detachment from the retina (PVD)<ref>PMID:21099453</ref>.


== 3D Structures of plasminogen ==
== Disease ==
PLN mutations are associated with ligneous conjunctivitis and other disorders which lead to development of pseudo membranes on mucosal surfaces<ref>PMID:19141167</ref>.


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
== Structural highlights ==
{{#tree:id=OrganizedByTopic|openlevels=0|
<scene name='46/465445/Cv/11'>PLN contains 7 domains</scene> which are: N-terminal, C-terminal serine protease catalytic domain and 5 kringle domains of ca. 80 residues.  The <scene name='46/465445/Cv/3'>kringle domain folds into a large loop containing 3 disulfide bonds</scene>, ''e.g.'' <scene name='46/465445/Cv/4'>Kringle 4</scene>. The kringle domain is important in protein-protein interaction with blood coagulation factors.<ref>PMID:22832192</ref>.
*<scene name='46/465445/Cv/12'>K ion coordination site</scene>. Water molecules are shown as red spheres.
*<scene name='46/465445/Cv/13'>Cl ion coordination site I</scene>.
*<scene name='46/465445/Cv/14'>Cl ion coordination site II</scene>.
*<scene name='46/465445/Cv/15'>Cl ion coordination site III</scene>.
*<scene name='46/465445/Cv/16'>Cl ion coordination site IV</scene>.


*Plasminogen
== 3D Structures of plasminogen ==
 
[[Plasminogen 3D structures]]
**[[4dur]], [[4duu]], [[4a5t]] – hPLG  2
 
*Plasminogen kringle 1
 
**[[1pkr]] - hPLG kringle 1 – human<BR />
**[[1cea]] - hPLG kringle 1 + e-aminocaprioic acid<BR />
**[[1hpj]], [[1hpk]] - hPLG kringle 1 + 6-aminohexanoic acid - NMR<BR />
**[[1ceb]] - hPLG kringle 1 + AMCHA<br />
**[[4cik]] - hPLG kringle 1 + inhibitor<br />
 
*Plasminogen kringle 2
 
**[[1b2i]] - hPLG kringle 2 (mutant) – NMR<BR />
**[[1i5k]] - hPLG kringle 2 (mutant) + M2 protein peptide<BR />
**[[2kj4]] – hPLG kringle 2 + M2 protein peptide – NMR<BR />
 
*Plasminogen kringle 3
 
**[[2l0s]] - hPLG kringle 3 – NMR<BR />
 
*Plasminogen kringle 4
 
**[[1pk4]], [[1pmk]], [[1pml]], [[1krn]] – hPLG kringle 4<BR />
**[[2pk4]] - hPLG kringle 4 + e-aminocaprioic acid
 
*Plasminogen kringle 5
 
**[[5hpg]] - hPLG kringle 5<BR />
**[[2knf]] - hPLG kringle 5 – NMR<BR />
 
*Plasminogen catalytic domain
 
**[[1qrz]], [[1ddj]], [[1rjx]] – hPLG catalytic domain (mutant)<br />
**[[1l4d]], [[1l4z]] - hPLG catalytic domain (mutant) + streptokinase α domain
 
*Plasmin
 
**[[1bml]] – hPLN catalytic domain + streptokinase<BR />
**[[1bui]] – hPLN light chain + staphylokinase
 
*Microplasmin


**[[3uir]] – hPLN + textilinin-1<br />
</StructureSection>
}}


== References ==
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]
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