4znr: Difference between revisions
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New page: '''Unreleased structure''' The entry 4znr is ON HOLD Authors: Jia, N., Jiang, Y.L., Cheng, W., Wang, H.W., Zhou, C.Z., Chen, Y. Description: Crystal structure of daniolysin1 complexed ... |
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==Crystal structure of Dln1 complexed with Man(alpha1-3)Man== | |||
<StructureSection load='4znr' size='340' side='right'caption='[[4znr]], [[Resolution|resolution]] 2.10Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4znr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZNR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZNR FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=PRD_900112:3alpha-alpha-mannobiose'>PRD_900112</scene></td></tr> | ||
[[Category: Chen | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4znr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4znr OCA], [https://pdbe.org/4znr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4znr RCSB], [https://www.ebi.ac.uk/pdbsum/4znr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4znr ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: | == Function == | ||
[[Category: | [https://www.uniprot.org/uniprot/AEP1_DANRE AEP1_DANRE] Pore-forming protein which might play a role in host defense. Exists as an antiparallel dimer in solution. Can also assemble into an octameric pore-like structure spanning the cell membrane. Oligomerization may be triggered by binding of the jacalin-type lectin domain to high-mannose cell-surface proteoglycans, and also requires a low pH environment. In vitro, shows high binding affinity for S.cerevisiae mannan and human HIV virus glycoprotein gp120.<ref>PMID:26711430</ref> | ||
[[Category: | == References == | ||
[[Category: | <references/> | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Danio rerio]] | |||
[[Category: Large Structures]] | |||
[[Category: Chen Y]] | |||
[[Category: Cheng W]] | |||
[[Category: Jia N]] | |||
[[Category: Jiang YL]] | |||
[[Category: Wang HW]] | |||
[[Category: Zhou CZ]] | |||
Latest revision as of 09:05, 20 March 2024
Crystal structure of Dln1 complexed with Man(alpha1-3)Man
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