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'''Unreleased structure'''


The entry 4zny is ON HOLD
==Structure of the human TSG101-UEV Domain in complex with the PTAP motif of the p19 gag protein of the Human T-cell Leukemia type I virus==
<StructureSection load='4zny' size='340' side='right'caption='[[4zny]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4zny]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_T-cell_leukemia_virus_type_I Human T-cell leukemia virus type I]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZNY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZNY FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zny OCA], [https://pdbe.org/4zny PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zny RCSB], [https://www.ebi.ac.uk/pdbsum/4zny PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zny ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TS101_HUMAN TS101_HUMAN] Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses.<ref>PMID:11916981</ref> <ref>PMID:17853893</ref> <ref>PMID:17556548</ref>


Authors: Camara-Artigas, A., Bacarizo, J.
==See Also==
 
*[[Tumor susceptibility gene 101|Tumor susceptibility gene 101]]
Description: Structure of the human TSG101-UEV Domain in complex with the PTAP motif of the p19 gag protein of the Human T-cell Leukemia type I virus
== References ==
[[Category: Unreleased Structures]]
<references/>
[[Category: Bacarizo, J]]
__TOC__
[[Category: Camara-Artigas, A]]
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Human T-cell leukemia virus type I]]
[[Category: Large Structures]]
[[Category: Bacarizo J]]
[[Category: Camara-Artigas A]]
Retrieved from "https://proteopedia.org/4zny"