2z5d: Difference between revisions

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[[Image:2z5d.gif|left|200px]]


{{Structure
==Human ubiquitin-conjugating enzyme E2 H==
|PDB= 2z5d |SIZE=350|CAPTION= <scene name='initialview01'>2z5d</scene>, resolution 2.10&Aring;
<StructureSection load='2z5d' size='340' side='right'caption='[[2z5d]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=NA:SODIUM ION'>NA</scene>
<table><tr><td colspan='2'>[[2z5d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1yh6 1yh6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z5D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Z5D FirstGlance]. <br>
|ACTIVITY= [http://en.wikipedia.org/wiki/Ubiquitin--protein_ligase Ubiquitin--protein ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.19 6.3.2.19]  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
|GENE= UBE2H ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2z5d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z5d OCA], [https://pdbe.org/2z5d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2z5d RCSB], [https://www.ebi.ac.uk/pdbsum/2z5d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2z5d ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/UBE2H_HUMAN UBE2H_HUMAN] Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Capable, in vitro, to ubiquitinate histone H2A.<ref>PMID:8132613</ref> <ref>PMID:20061386</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z5/2z5d_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2z5d ConSurf].
<div style="clear:both"></div>


'''Human ubiquitin-conjugating enzyme E2 H'''
==See Also==
 
*[[3D structures of ubiquitin conjugating enzyme|3D structures of ubiquitin conjugating enzyme]]
 
== References ==
==About this Structure==
<references/>
2Z5D is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry 1YH6. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z5D OCA].
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Ubiquitin--protein ligase]]
[[Category: Arrowsmith C]]
[[Category: Arrowsmith, C.]]
[[Category: Battaile KP]]
[[Category: Battaile, K P.]]
[[Category: Bochkarev A]]
[[Category: Bochkarev, A.]]
[[Category: Cui H]]
[[Category: Cui, H.]]
[[Category: Dhe-Paganon S]]
[[Category: Dhe-Paganon, S.]]
[[Category: Edwards A]]
[[Category: Edwards, A.]]
[[Category: Mackenzie F]]
[[Category: Mackenzie, F.]]
[[Category: Newman EM]]
[[Category: Newman, E M.]]
[[Category: Sundstrom M]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Walker JR]]
[[Category: Sundstrom, M.]]
[[Category: Walker, J R.]]
[[Category: NA]]
[[Category: ligase]]
[[Category: sgc]]
[[Category: structural genomic]]
[[Category: structural genomics consortium]]
[[Category: ube2h]]
[[Category: ubiquitin]]
[[Category: ubiquitin-conjugating enzyme]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:52:16 2008''
Retrieved from "https://proteopedia.org/2z5d"