2z5z: Difference between revisions

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[[Image:2z5z.jpg|left|200px]]


{{Structure
==Crystal structure of the complex of buffalo Lactoperoxidase with fluoride ion at 3.5A resolution==
|PDB= 2z5z |SIZE=350|CAPTION= <scene name='initialview01'>2z5z</scene>, resolution 3.50&Aring;
<StructureSection load='2z5z' size='340' side='right'caption='[[2z5z]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=F:FLUORIDE+ION'>F</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene> and <scene name='pdbligand=OSM:1-(OXIDOSULFANYL)METHANAMINE'>OSM</scene>
<table><tr><td colspan='2'>[[2z5z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bubalus_bubalis Bubalus bubalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z5Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Z5Z FirstGlance]. <br>
|ACTIVITY= [http://en.wikipedia.org/wiki/Peroxidase Peroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.7 1.11.1.7]  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
|GENE=  
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=F:FLUORIDE+ION'>F</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=OSM:1-(OXIDOSULFANYL)METHANAMINE'>OSM</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2z5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z5z OCA], [https://pdbe.org/2z5z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2z5z RCSB], [https://www.ebi.ac.uk/pdbsum/2z5z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2z5z ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PERL_BUBBU PERL_BUBBU] Antimicrobial agent which utilizes hydrogen peroxide and thiocyanate (SCN) to generate the antimicrobial substance hypothiocyanous acid (HOSCN). May protect the udder from infection and promote growth in newborn calves. Inhibits growth of the following bacterial species: E.coli, K.pneumoniae, P.aeruginosa, S.sonnei, S.saphrophyticus, S.epidermidis, and S.dysenteriae.<ref>PMID:12071645</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z5/2z5z_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2z5z ConSurf].
<div style="clear:both"></div>


'''Crystal structure of the complex of buffalo Lactoperoxidase with fluoride ion at 3.5A resolution'''
==See Also==
 
*[[Lactoperoxidase|Lactoperoxidase]]
 
== References ==
==About this Structure==
<references/>
2Z5Z is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Bubalus_bubalis Bubalus bubalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z5Z OCA].
__TOC__
</StructureSection>
[[Category: Bubalus bubalis]]
[[Category: Bubalus bubalis]]
[[Category: Peroxidase]]
[[Category: Large Structures]]
[[Category: Protein complex]]
[[Category: Bhushan A]]
[[Category: Bhushan, A.]]
[[Category: Jain R]]
[[Category: Jain, R.]]
[[Category: Kaur P]]
[[Category: Kaur, P.]]
[[Category: Sharma S]]
[[Category: Sharma, S.]]
[[Category: Sheikh IA]]
[[Category: Sheikh, I A.]]
[[Category: Singh N]]
[[Category: Singh, N.]]
[[Category: Singh TP]]
[[Category: Singh, T P.]]
[[Category: Srinivasan A]]
[[Category: Srinivasan, A.]]
[[Category: CA]]
[[Category: F]]
[[Category: HEM]]
[[Category: IOD]]
[[Category: OSM]]
[[Category: buffalo]]
[[Category: complex]]
[[Category: fluoride]]
[[Category: lactoperoxidase]]
[[Category: oxidoreductase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:52:25 2008''
Retrieved from "https://proteopedia.org/2z5z"