4ztp: Difference between revisions
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New page: '''Unreleased structure''' The entry 4ztp is ON HOLD Authors: Pan, R, Kong, X-P Description: Fab structure of rabbit monoclonal antibody R53 targeting an epitope in HIV-1 gp120 C4 regi... |
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The | ==Fab structure of rabbit monoclonal antibody R53 targeting an epitope in HIV-1 gp120 C4 region== | ||
<StructureSection load='4ztp' size='340' side='right'caption='[[4ztp]], [[Resolution|resolution]] 1.63Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4ztp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZTP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZTP FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.63Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ztp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ztp OCA], [https://pdbe.org/4ztp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ztp RCSB], [https://www.ebi.ac.uk/pdbsum/4ztp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ztp ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The fourth conserved region (C4) in the HIV-1 envelope glycoprotein (Env) gp120 is a structural element that is important for its function, as it binds to both the receptor CD4 and the co-receptor CCR5/CXCR4. It has long been known that this region is highly immunogenic and that it harbors B-cell as well as T-cell epitopes. It is the target of a number of antibodies in animal studies, which are called CD4-blockers. However, the mechanism by which the virus shields itself from such antibody responses is not known. Here, we determined the crystal structure of R53 in complex with its epitope peptide using a novel anti-C4 rabbit monoclonal antibody R53. Our data show that although the epitope of R53 covers a highly conserved sequence (433)AMYAPPI(439), it is not available in the gp120 trimer and in the CD4-bound conformation. Our results suggest a masking mechanism to explain how HIV-1 protects this critical region from the human immune system. | |||
Structural analysis of a novel rabbit monoclonal antibody R53 targeting an epitope in HIV-1 gp120 C4 region critical for receptor and co-receptor binding.,Pan R, Chen Y, Vaine M, Hu G, Wang S, Lu S, Kong XP Emerg Microbes Infect. 2015 Jul;4(7):e44. doi: 10.1038/emi.2015.44. Epub 2015 Jul, 15. PMID:26251831<ref>PMID:26251831</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
[[Category: | <div class="pdbe-citations 4ztp" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Oryctolagus cuniculus]] | |||
[[Category: Kong X-P]] | |||
[[Category: Pan R]] | |||
Latest revision as of 08:23, 27 September 2023
Fab structure of rabbit monoclonal antibody R53 targeting an epitope in HIV-1 gp120 C4 region
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