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[[Image:333d.gif|left|200px]]


{{Structure
==THE CRYSTAL STRUCTURE OF AN RNA OLIGOMER INCORPORATING TANDEM ADENOSINE-INOSINE MISMATCHES==
|PDB= 333d |SIZE=350|CAPTION= <scene name='initialview01'>333d</scene>, resolution 2.520&Aring;
<StructureSection load='333d' size='340' side='right'caption='[[333d]], [[Resolution|resolution]] 2.52&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=CA:CALCIUM ION'>CA</scene>
<table><tr><td colspan='2'>[[333d]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=333D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=333D FirstGlance]. <br>
|ACTIVITY=
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.52&#8491;</td></tr>
|GENE=
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=333d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=333d OCA], [https://pdbe.org/333d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=333d RCSB], [https://www.ebi.ac.uk/pdbsum/333d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=333d ProSAT]</span></td></tr>
 
</table>
'''THE CRYSTAL STRUCTURE OF AN RNA OLIGOMER INCORPORATING TANDEM ADENOSINE-INOSINE MISMATCHES'''
__TOC__
 
</StructureSection>
 
[[Category: Large Structures]]
==Overview==
[[Category: Baeyens KJ]]
The X-ray crystallographic structure of the RNA duplex [r(CGCAIGCG)]2 has been refined to 2.5 A. It shows a symmetric internal loop of two non-Watson-Crick base pairs which form in the middle of the duplex. The tandem A-I/I-A pairs are related by a crystallographic two-fold axis. Both A(anti)-I(anti) mismatches are in a head-to-head conformation forming hydrogen bonds using the Watson-Crick positions. The octamer duplexes stack above one another in the cell forming a pseudo-infinite helix throughout the crystal. A hydrated calcium ion bridges between the 3'-terminal of one molecule and the backbone of another. The tandem A-I mismatches are incorporated with only minor distortion to the backbone. This is in contrast to the large helical perturbations often produced by sheared G-A pairs in RNA oligonucleotides.
[[Category: Carter RJ]]
 
[[Category: Holbrook SR]]
==About this Structure==
[[Category: SantaLucia Jr J]]
333D is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=333D OCA].  
[[Category: Turner DH]]
 
==Reference==
The crystal structure of an RNA oligomer incorporating tandem adenosine-inosine mismatches., Carter RJ, Baeyens KJ, SantaLucia J, Turner DH, Holbrook SR, Nucleic Acids Res. 1997 Oct 15;25(20):4117-22. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9321667 9321667]
[[Category: Protein complex]]
[[Category: Baeyens, K J.]]
[[Category: Carter, R J.]]
[[Category: Holbrook, S R.]]
[[Category: Jr., J SantaLucia.]]
[[Category: Turner, D H.]]
[[Category: CA]]
[[Category: a-rna]]
[[Category: double helix]]
[[Category: internal loop]]
[[Category: mismatched]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:54:44 2008''

Latest revision as of 08:39, 7 February 2024

THE CRYSTAL STRUCTURE OF AN RNA OLIGOMER INCORPORATING TANDEM ADENOSINE-INOSINE MISMATCHES

333d, resolution 2.52Å

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