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==Ras-related protein Rap1B with GDP==
==Ras-related protein Rap1B with GDP==
<StructureSection load='3x1w' size='340' side='right' caption='[[3x1w]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
<StructureSection load='3x1w' size='340' side='right'caption='[[3x1w]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3x1w]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3X1W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3X1W FirstGlance]. <br>
<table><tr><td colspan='2'>[[3x1w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3X1W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3X1W FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.2&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3x1z|3x1z]], [[3x1y|3x1y]], [[3x1x|3x1x]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3x1w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3x1w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3x1w RCSB], [http://www.ebi.ac.uk/pdbsum/3x1w PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3x1w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3x1w OCA], [https://pdbe.org/3x1w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3x1w RCSB], [https://www.ebi.ac.uk/pdbsum/3x1w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3x1w ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/RAP1B_RAT RAP1B_RAT]] GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function (By similarity).  
[https://www.uniprot.org/uniprot/RAP1B_RAT RAP1B_RAT] GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 3x1w" style="background-color:#fffaf0;"></div>
==See Also==
*[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Akashi, S]]
[[Category: Large Structures]]
[[Category: Ikegami, T]]
[[Category: Rattus norvegicus]]
[[Category: Noguchi, H]]
[[Category: Akashi S]]
[[Category: Park, S Y]]
[[Category: Ikegami T]]
[[Category: Tame, J R.H]]
[[Category: Noguchi H]]
[[Category: Unzai, S]]
[[Category: Park SY]]
[[Category: Signal transduction]]
[[Category: Tame JRH]]
[[Category: Signaling protein]]
[[Category: Unzai S]]
Retrieved from "https://proteopedia.org/3x1w"