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New page: left|200px {{Structure |PDB= 3bej |SIZE=350|CAPTION= <scene name='initialview01'>3bej</scene>, resolution 1.90Å |SITE= <scene name='pdbsite=AC1:Yt3+Binding+Site+...
 
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[[Image:3bej.jpg|left|200px]]


{{Structure
==Structure of human FXR in complex with MFA-1 and co-activator peptide==
|PDB= 3bej |SIZE=350|CAPTION= <scene name='initialview01'>3bej</scene>, resolution 1.90&Aring;
<StructureSection load='3bej' size='340' side='right'caption='[[3bej]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
|SITE= <scene name='pdbsite=AC1:Yt3+Binding+Site+For+Residue+A+1'>AC1</scene>, <scene name='pdbsite=AC2:Yt3+Binding+Site+For+Residue+B+2'>AC2</scene>, <scene name='pdbsite=AC3:Muf+Binding+Site+For+Residue+A+473'>AC3</scene> and <scene name='pdbsite=AC4:Muf+Binding+Site+For+Residue+B+1'>AC4</scene>
== Structural highlights ==
|LIGAND= <scene name='pdbligand=YT3:YTTRIUM+(III)+ION'>YT3</scene> and <scene name='pdbligand=MUF:'>MUF</scene>
<table><tr><td colspan='2'>[[3bej]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BEJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BEJ FirstGlance]. <br>
|ACTIVITY= [http://en.wikipedia.org/wiki/Histone_acetyltransferase Histone acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.48 2.3.1.48]  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
|GENE= NR1H4, BAR, FXR, HRR1, RIP14 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), NCOA1, SRC1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MUF:(8ALPHA,10ALPHA,13ALPHA,17BETA)-17-[(4-HYDROXYPHENYL)CARBONYL]ANDROSTA-3,5-DIENE-3-CARBOXYLIC+ACID'>MUF</scene>, <scene name='pdbligand=YT3:YTTRIUM+(III)+ION'>YT3</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bej FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bej OCA], [https://pdbe.org/3bej PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bej RCSB], [https://www.ebi.ac.uk/pdbsum/3bej PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bej ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NR1H4_HUMAN NR1H4_HUMAN] Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus.<ref>PMID:10334992</ref> <ref>PMID:10334993</ref> <ref>PMID:12815072</ref> <ref>PMID:15471871</ref> <ref>PMID:12718892</ref> <ref>PMID:18621523</ref> <ref>PMID:19410460</ref> <ref>PMID:19586769</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/be/3bej_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bej ConSurf].
<div style="clear:both"></div>


'''Structure of human FXR in complex with MFA-1 and co-activator peptide'''
==See Also==
 
*[[Bile acid receptor 3D structures|Bile acid receptor 3D structures]]
 
== References ==
==About this Structure==
<references/>
3BEJ is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BEJ OCA].
__TOC__
[[Category: Histone acetyltransferase]]
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein complex]]
[[Category: Large Structures]]
[[Category: Becker, J W.]]
[[Category: Becker JW]]
[[Category: Parthasarathy, G]]
[[Category: Parthasarathy G]]
[[Category: Soisson, S M.]]
[[Category: Soisson SM]]
[[Category: MUF]]
[[Category: YT3]]
[[Category: activator]]
[[Category: acyltransferase]]
[[Category: alternative splicing]]
[[Category: bar]]
[[Category: bile acid receptor]]
[[Category: chromosomal rearrangement]]
[[Category: dna-binding]]
[[Category: fxr]]
[[Category: metal-binding]]
[[Category: nhr]]
[[Category: nr1h4]]
[[Category: nuclear receptor]]
[[Category: nucleus]]
[[Category: phosphoprotein]]
[[Category: polymorphism]]
[[Category: proto-oncogene]]
[[Category: repressor]]
[[Category: transcription]]
[[Category: transcription regulation]]
[[Category: transcription regulator]]
[[Category: transcription/transferase complex]]
[[Category: transferase]]
[[Category: ubl conjugation]]
[[Category: zinc]]
[[Category: zinc-finger]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:58:17 2008''

Latest revision as of 09:28, 21 February 2024

Structure of human FXR in complex with MFA-1 and co-activator peptide

3bej, resolution 1.90Å

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