Corticosteroid-binding globulin: Difference between revisions

'''Corticosteroid-binding globulin''' (CBG) is a blood plasma protein 50 to 60 kDa in size <ref>PMID:13395526 </ref>,<ref>PMID:7074030 </ref>.  Although it is a member of the serine protease inhibitor (SERPIN) structural family, it does not have any known intrinsic serine protease inhibitor activity <ref>PMID:3143075 </ref>.  Its physiological function is conventionally thought to be the transport of the weakly water-soluble hormone, cortisol, throughout the circulation <ref>PMID:13395526 </ref>,<ref>PMID:7074030 </ref>.  Structural studies of native rat CBG <ref>PMID:17644521 </ref> and a cleaved human CBG-antitrypsin chimera <ref>PMID:18513745 </ref> have corroborated earlier biochemical studies showing that cortisol binds to CBG with a one-to-one stoichiometry.  Additionally, CBG is believed to buffer the concentration of free cortisol in the blood, keeping the level constant despite its pulsatile secretion pattern <ref>PMID:9751481 </ref>.  CBG is also thought to participate in the stress response by releasing cortisol specifically at inflammatory sites upon cleavage by human neutrophil elastase between residues 344 and 345<ref>PMID:3143075 </ref>.

==Gene==

Corticosteroid-binding globulin is a very important blood protein that functions not merely as a passive carrier of cortisol, but also as a ready reservoir of the hormone for release at sites of inflammation.  It also acts as a buffer to keep the level of blood cortisol constant and thus, maintains homeostasis.  Work is still being done, not just in fully elucidating the molecular mechanism of its function, but also in its interaction with various tissues in the body, and this can have great implications on our understanding of metabolic diseases, as well as infection and immunity.

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[[2v95]] – rSer-A6 – rat<br />

[[4bb2]] – hSer-A6 (mutant) + progesterone <br />

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