5bt5: Difference between revisions
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New page: '''Unreleased structure''' The entry 5bt5 is ON HOLD Authors: Tallant, C., Hay, D., Krojer, T., Nunez-Alonso, G., Picaud, S., Newman, J.A., Fedorov, O., von Delft, F., Arrowsmith, C.H.,... |
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==Crystal structure of BRD2 second bromodomain in complex with SGC-CBP30 chemical probe== | |||
<StructureSection load='5bt5' size='340' side='right'caption='[[5bt5]], [[Resolution|resolution]] 1.40Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5bt5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BT5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5BT5 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2LO:2-[2-(3-CHLORO-4-METHOXYPHENYL)ETHYL]-5-(3,5-DIMETHYL-1,2-OXAZOL-4-YL)-1-[(2S)-2-(MORPHOLIN-4-YL)PROPYL]-1H-BENZIMIDAZOLE'>2LO</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5bt5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bt5 OCA], [https://pdbe.org/5bt5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5bt5 RCSB], [https://www.ebi.ac.uk/pdbsum/5bt5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5bt5 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/BRD2_HUMAN BRD2_HUMAN] May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.<ref>PMID:18406326</ref> | |||
==See Also== | |||
*[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]] | |||
== References == | |||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Arrowsmith CH]] | ||
[[Category: | [[Category: Bountra C]] | ||
[[Category: | [[Category: Brennan PE]] | ||
[[Category: | [[Category: Edwards AM]] | ||
[[Category: | [[Category: Fedorov O]] | ||
[[Category: | [[Category: Hay D]] | ||
[[Category: | [[Category: Knapp S]] | ||
[[Category: | [[Category: Krojer T]] | ||
[[Category: | [[Category: Newman JA]] | ||
[[Category: | [[Category: Nunez-Alonso G]] | ||
[[Category: Picaud S]] | |||
[[Category: Tallant C]] | |||
[[Category: Von Delft F]] | |||
Latest revision as of 11:43, 9 May 2024
Crystal structure of BRD2 second bromodomain in complex with SGC-CBP30 chemical probe
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