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==Cellobionic acid phosphorylase - cellobionic acid complex==
==Cellobionic acid phosphorylase - cellobionic acid complex==
<StructureSection load='4zlf' size='340' side='right' caption='[[4zlf]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
<StructureSection load='4zlf' size='340' side='right'caption='[[4zlf]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4zlf]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZLF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZLF FirstGlance]. <br>
<table><tr><td colspan='2'>[[4zlf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharophagus_degradans_2-40 Saccharophagus degradans 2-40]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZLF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZLF FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CEZ:4-O-BETA-D-GLUCOPYRANOSYL-D-GLUCONIC+ACID'>CEZ</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4zle|4zle]], [[4zlg|4zlg]], [[4zli|4zli]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CEZ:4-O-BETA-D-GLUCOPYRANOSYL-D-GLUCONIC+ACID'>CEZ</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cellobionic_acid_phosphorylase Cellobionic acid phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.321 2.4.1.321] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zlf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zlf OCA], [https://pdbe.org/4zlf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zlf RCSB], [https://www.ebi.ac.uk/pdbsum/4zlf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zlf ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zlf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zlf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4zlf RCSB], [http://www.ebi.ac.uk/pdbsum/4zlf PDBsum]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Function ==
== Publication Abstract from PubMed ==
[https://www.uniprot.org/uniprot/Q21MB1_SACD2 Q21MB1_SACD2]
A novel phosphorylase was characterized as new member of glycoside hydrolase family 94 from the cellulolytic bacterium Xanthomonas campestris and the fungus Neurospora crassa. The enzyme catalyzed reversible phosphorolysis of cellobionic acid. We propose 4-O-beta-D-glucopyranosyl-D-gluconic acid: phosphate alpha-D-glucosyltransferase as the systematic name and cellobionic acid phosphorylase as the short names for the novel enzyme. Several cellulolytic fungi of the phylum Ascomycota also possess homologous proteins. We, therefore, suggest that the enzyme plays a crucial role in cellulose degradation where cellobionic acid as oxidized cellulolytic product is converted into alpha-D-glucose 1-phosphate and D-gluconic acid to enter glycolysis and the pentose phosphate pathway, respectively.
 
Discovery of cellobionic acid phosphorylase in cellulolytic bacteria and fungi.,Nihira T, Saito Y, Nishimoto M, Kitaoka M, Igarashi K, Ohtsubo K, Nakai H FEBS Lett. 2013 Nov 1;587(21):3556-61. doi: 10.1016/j.febslet.2013.09.014. Epub, 2013 Sep 19. PMID:24055472<ref>PMID:24055472</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Cellobionic acid phosphorylase]]
[[Category: Large Structures]]
[[Category: Arakawa, T]]
[[Category: Saccharophagus degradans 2-40]]
[[Category: Fushinobu, S]]
[[Category: Arakawa T]]
[[Category: Nam, Y W]]
[[Category: Fushinobu S]]
[[Category: Glycoside hydrolase family 94]]
[[Category: Nam YW]]
[[Category: Intracellular enzyme]]
[[Category: Oxidative cellulose degradation system]]
[[Category: Transferase]]
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