4d0g: Difference between revisions

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==Structure of Rab14 in complex with Rab-Coupling Protein (RCP)==
==Structure of Rab14 in complex with Rab-Coupling Protein (RCP)==
<StructureSection load='4d0g' size='340' side='right' caption='[[4d0g]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='4d0g' size='340' side='right'caption='[[4d0g]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4d0g]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D0G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4D0G FirstGlance]. <br>
<table><tr><td colspan='2'>[[4d0g]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D0G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4D0G FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4d0g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d0g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4d0g RCSB], [http://www.ebi.ac.uk/pdbsum/4d0g PDBsum]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4d0g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d0g OCA], [https://pdbe.org/4d0g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4d0g RCSB], [https://www.ebi.ac.uk/pdbsum/4d0g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4d0g ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/RAB14_HUMAN RAB14_HUMAN]] Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes (By similarity). Regulates, together with its guanine nucleotide exchange factor DENND6A, the specific endocytic transport of ADAM10, N-cadherin/CDH2 shedding and cell-cell adhesion.<ref>PMID:22595670</ref> [[http://www.uniprot.org/uniprot/RFIP1_HUMAN RFIP1_HUMAN]] A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis.<ref>PMID:11786538</ref> <ref>PMID:15181150</ref> <ref>PMID:15355514</ref> <ref>PMID:16920206</ref> 
[https://www.uniprot.org/uniprot/RAB14_HUMAN RAB14_HUMAN] Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes (By similarity). Regulates, together with its guanine nucleotide exchange factor DENND6A, the specific endocytic transport of ADAM10, N-cadherin/CDH2 shedding and cell-cell adhesion.<ref>PMID:22595670</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 4d0g" style="background-color:#fffaf0;"></div>
==See Also==
*[[Ras-related protein Rab 3D structures|Ras-related protein Rab 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Khan, A R]]
[[Category: Homo sapiens]]
[[Category: Lall, P]]
[[Category: Large Structures]]
[[Category: Effector recruitment]]
[[Category: Khan AR]]
[[Category: Endosomal trafficking]]
[[Category: Lall P]]
[[Category: Hydrolase]]
[[Category: Rab14 gtpase]]
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