Tryptase: Difference between revisions
From Proteopedia
Jump to navigationJump to search
Michal Harel (talk | contribs) No edit summary |
Michal Harel (talk | contribs) No edit summary |
||
| (11 intermediate revisions by 2 users not shown) | |||
| Line 1: | Line 1: | ||
<StructureSection load='2zeb' size='350' side='right' caption='Human tryptase β-2 tetramer complex with piperidine derivative inhibitor, [[2zeb]]' scene='46/465443/Cv/1' pspeed='8'> | |||
== Function == | |||
'''Tryptase''' (TRP) is a serine protease found in mast cells<ref>PMID:15200544</ref>. | |||
== Relevance == | |||
TRP is used as a marker for mast cell activation<ref>PMID:1607547</ref>. Inhibitors of TRP have therapeutic potential for treating allergic or inflammatory disorders such as asthma and inflammatory bowel diseases<ref>PMID:16640553</ref>. | |||
== Structural highlights == | |||
The biological assembly of Human tryptase is <scene name='46/465443/Cv/5'>homotetramer</scene> ([[2zeb]]). The <scene name='46/465443/Cv/6'>piperidine derivative TRP inhibitor interacts with both subunits of TRP</scene><ref>PMID:18272363</ref>. Water molecules are shown as red spheres. | |||
</StructureSection> | |||
== 3D Structures of tryptase == | == 3D Structures of tryptase == | ||
| Line 11: | Line 17: | ||
**[[1lto]] – hTRP-α1 - human<br /> | **[[1lto]] – hTRP-α1 - human<br /> | ||
**[[2f9o]] - hTRP-α1 (mutant) | **[[2f9o]] - hTRP-α1 (mutant)<br /> | ||
**[[5wi6]] - hTRP-α/β1 (mutant)<br /> | |||
*Tryptase complex with inhibitor | *Tryptase complex with inhibitor | ||
| Line 18: | Line 25: | ||
**[[2f9n]], [[2f9p]] - hTRP-α1 (mutant) + leupeptin<br /> | **[[2f9n]], [[2f9p]] - hTRP-α1 (mutant) + leupeptin<br /> | ||
**[[2bm2]], [[2fww]] - hTRP-β2 + piperidine derivative<br /> | **[[2bm2]], [[2fww]] - hTRP-β2 + piperidine derivative<br /> | ||
**[[4a6l]] - hTRP-α/β1 + piperidine derivative<br /> | **[[5f03]] - hTRP-β2 + oxazolidine derivative<br /> | ||
**[[4a6l]], [[6p0p]] - hTRP-α/β1 + piperidine derivative<br /> | |||
**[[4mpu]], [[4mpv]], [[4mpw]], [[4mpx]], [[4mqa]] - hTRP-α/β1 + drug<br /> | **[[4mpu]], [[4mpv]], [[4mpw]], [[4mpx]], [[4mqa]] - hTRP-α/β1 + drug<br /> | ||
**[[6vvu]] - hTRP-α/1 + antibody<br /> | |||
**[[6o1f]] - hTRP-α/β1 + trypsin inhibitor + antibody<br /> | |||
**[[2fxr]] - hTRP-β2 + ketone inhibitor<br /> | **[[2fxr]] - hTRP-β2 + ketone inhibitor<br /> | ||
**[[2fpz]] - hTRP-β2 + benzimidazole inhibitor<br /> | **[[2fpz]] - hTRP-β2 + benzimidazole inhibitor<br /> | ||
| Line 25: | Line 35: | ||
**[[3v7t]] - hTRP-β2 + tropanylamide inhibitor<br /> | **[[3v7t]] - hTRP-β2 + tropanylamide inhibitor<br /> | ||
}} | }} | ||
== References == | |||
<references/> | |||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Latest revision as of 10:07, 28 January 2024
| ||||||||||||
3D Structures of tryptase
Updated on 28-January-2024
