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[[Image:3c5i.jpg|left|200px]]


{{Structure
==Crystal structure of Plasmodium knowlesi choline kinase, PKH_134520==
|PDB= 3c5i |SIZE=350|CAPTION= <scene name='initialview01'>3c5i</scene>, resolution 2.200&Aring;
<StructureSection load='3c5i' size='340' side='right'caption='[[3c5i]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
|SITE= <scene name='pdbsite=AC1:Mg+Binding+Site+For+Residue+A+370'>AC1</scene>, <scene name='pdbsite=AC2:Mg+Binding+Site+For+Residue+B+370'>AC2</scene>, <scene name='pdbsite=AC3:Mg+Binding+Site+For+Residue+C+370'>AC3</scene>, <scene name='pdbsite=AC4:Mg+Binding+Site+For+Residue+D+370'>AC4</scene>, <scene name='pdbsite=AC5:Ca+Binding+Site+For+Residue+A+371'>AC5</scene>, <scene name='pdbsite=AC6:Ca+Binding+Site+For+Residue+B+371'>AC6</scene>, <scene name='pdbsite=AC7:Ca+Binding+Site+For+Residue+C+371'>AC7</scene>, <scene name='pdbsite=AC8:Ca+Binding+Site+For+Residue+D+371'>AC8</scene>, <scene name='pdbsite=AC9:Cht+Binding+Site+For+Residue+A+1001'>AC9</scene>, <scene name='pdbsite=BC1:Cht+Binding+Site+For+Residue+B+1001'>BC1</scene>, <scene name='pdbsite=BC2:Unl+Binding+Site+For+Residue+D+372'>BC2</scene>, <scene name='pdbsite=BC3:Gol+Binding+Site+For+Residue+A+1002'>BC3</scene>, <scene name='pdbsite=BC4:Gol+Binding+Site+For+Residue+B+1003'>BC4</scene>, <scene name='pdbsite=BC5:Gol+Binding+Site+For+Residue+A+1003'>BC5</scene>, <scene name='pdbsite=BC6:Gol+Binding+Site+For+Residue+C+373'>BC6</scene>, <scene name='pdbsite=BC7:Gol+Binding+Site+For+Residue+D+373'>BC7</scene>, <scene name='pdbsite=BC8:Gol+Binding+Site+For+Residue+C+374'>BC8</scene>, <scene name='pdbsite=BC9:Gol+Binding+Site+For+Residue+B+1004'>BC9</scene>, <scene name='pdbsite=CC1:Gol+Binding+Site+For+Residue+C+375'>CC1</scene>, <scene name='pdbsite=CC2:Gol+Binding+Site+For+Residue+D+374'>CC2</scene> and <scene name='pdbsite=CC3:Gol+Binding+Site+For+Residue+D+375'>CC3</scene>
== Structural highlights ==
|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CHT:CHOLINE+ION'>CHT</scene>, <scene name='pdbligand=UNL:'>UNL</scene> and <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
<table><tr><td colspan='2'>[[3c5i]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_knowlesi Plasmodium knowlesi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C5I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3C5I FirstGlance]. <br>
|ACTIVITY=
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
|GENE= PKH_134520 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5850 Plasmodium knowlesi])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CHT:CHOLINE+ION'>CHT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=UNL:UNKNOWN+LIGAND'>UNL</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3c5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c5i OCA], [https://pdbe.org/3c5i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3c5i RCSB], [https://www.ebi.ac.uk/pdbsum/3c5i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3c5i ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/D0VWT1_PLAKN D0VWT1_PLAKN]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c5/3c5i_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3c5i ConSurf].
<div style="clear:both"></div>


'''Crystal structure of Plasmodium knowlesi choline kinase, PKH_134520'''
==See Also==
 
*[[Choline kinase 3D structures|Choline kinase 3D structures]]
 
__TOC__
==About this Structure==
</StructureSection>
3C5I is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Plasmodium_knowlesi Plasmodium knowlesi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C5I OCA].
[[Category: Large Structures]]
[[Category: Plasmodium knowlesi]]
[[Category: Plasmodium knowlesi]]
[[Category: Protein complex]]
[[Category: Arrowsmith CH]]
[[Category: Arrowsmith, C H.]]
[[Category: Artz JD]]
[[Category: Artz, J D.]]
[[Category: Bochkarev A]]
[[Category: Bochkarev, A.]]
[[Category: Bountra C]]
[[Category: Bountra, C.]]
[[Category: Cossar D]]
[[Category: Cossar, D.]]
[[Category: Edwards AM]]
[[Category: Edwards, A M.]]
[[Category: Hills T]]
[[Category: Hills, T.]]
[[Category: Hui R]]
[[Category: Hui, R.]]
[[Category: Kozieradzki I]]
[[Category: Kozieradzki, I.]]
[[Category: Lew J]]
[[Category: Lew, J.]]
[[Category: Schapira M]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Senesterra G]]
[[Category: Schapira, M.]]
[[Category: Vedadi M]]
[[Category: Senesterra, G.]]
[[Category: Wasney G]]
[[Category: Vedadi, M.]]
[[Category: Weigelt J]]
[[Category: Wasney, G.]]
[[Category: Wernimont AK]]
[[Category: Weigelt, J.]]
[[Category: Xiao T]]
[[Category: Wernimont, A K.]]
[[Category: Xiao, T.]]
[[Category: CA]]
[[Category: CHT]]
[[Category: GOL]]
[[Category: MG]]
[[Category: UNL]]
[[Category: choline]]
[[Category: kinase]]
[[Category: malaria]]
[[Category: plasmodium knowlesi]]
[[Category: sgc]]
[[Category: structural genomic]]
[[Category: structural genomics consortium]]
[[Category: transferase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 19:02:40 2008''

Latest revision as of 12:22, 30 August 2023

Crystal structure of Plasmodium knowlesi choline kinase, PKH_134520

3c5i, resolution 2.20Å

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