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New page: '''Unreleased structure''' The entry 5c1v is ON HOLD until Paper Publication Authors: Guasch, A., Fita, I., Perez-Luque, R., Aparicio, D., Aranguren-Ibanez, A., Perez-Riba, M. Descript...
 
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'''Unreleased structure'''


The entry 5c1v is ON HOLD  until Paper Publication
==CRYSTAL STRUCTURE ANALYSIS OF CATALYTIC SUBUNIT OF HUMAN CALCINEURIN==
<StructureSection load='5c1v' size='340' side='right'caption='[[5c1v]], [[Resolution|resolution]] 3.35&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5c1v]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C1V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5C1V FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.35&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5c1v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c1v OCA], [https://pdbe.org/5c1v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5c1v RCSB], [https://www.ebi.ac.uk/pdbsum/5c1v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5c1v ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PP2BA_HUMAN PP2BA_HUMAN] Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L, HSPB1 and SSH1.<ref>PMID:15671020</ref> <ref>PMID:18838687</ref>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
A limited repertoire of PPP family of serine/threonine phosphatases with a highly conserved catalytic domain acts on thousands of protein targets to orchestrate myriad central biological roles. A major structural reorganization of human calcineurin, a ubiquitous Ser/Thr PPP regulated by calcium and calmodulin and targeted by immunosuppressant drugs cyclosporin A and FK506, is unveiled here. The new conformation involves trans- to cis-isomerization of proline in the SAPNY sequence, highly conserved across PPPs, and remodels the main regulatory site where NFATc transcription factors bind. Transitions between cis- and trans-conformations may involve peptidyl prolyl isomerases such as cyclophilin A and FKBP12, which are known to physically interact with and modulate calcineurin even in the absence of immunosuppressant drugs. Alternative conformations in PPPs provide a new perspective on interactions with substrates and other protein partners and may foster development of more specific inhibitors as drug candidates.


Authors: Guasch, A., Fita, I., Perez-Luque, R., Aparicio, D., Aranguren-Ibanez, A., Perez-Riba, M.
Calcineurin Undergoes a Conformational Switch Evoked via Peptidyl-Prolyl Isomerization.,Guasch A, Aranguren-Ibanez A, Perez-Luque R, Aparicio D, Martinez-Hoyer S, Mulero MC, Serrano-Candelas E, Perez-Riba M, Fita I PLoS One. 2015 Aug 6;10(8):e0134569. doi: 10.1371/journal.pone.0134569., eCollection 2015. PMID:26248042<ref>PMID:26248042</ref>


Description: CRYSTAL STRUCTURE ANALYSIS OF CATALYTIC SUBUNIT OF HUMAN CALCINEURIN
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
[[Category: Aranguren-Ibanez, A]]
<div class="pdbe-citations 5c1v" style="background-color:#fffaf0;"></div>
[[Category: Perez-Riba, M]]
 
[[Category: Aparicio, D]]
==See Also==
[[Category: Perez-Luque, R]]
*[[Calcineurin 3D structures|Calcineurin 3D structures]]
[[Category: Fita, I]]
== References ==
[[Category: Guasch, A]]
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Aparicio D]]
[[Category: Aranguren-Ibanez A]]
[[Category: Fita I]]
[[Category: Guasch A]]
[[Category: Perez-Luque R]]
[[Category: Perez-Riba M]]
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