5c1w: Difference between revisions
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New page: '''Unreleased structure''' The entry 5c1w is ON HOLD Authors: Yan, Y. Description: Category: Unreleased Structures Category: Yan, Y |
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==PDE10 complexed with 4,6-dichloro-2-cyclopropyl-5-methyl-pyrimidine== | |||
<StructureSection load='5c1w' size='340' side='right'caption='[[5c1w]], [[Resolution|resolution]] 1.70Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5c1w]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C1W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5C1W FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4XS:4,6-DICHLORO-2-CYCLOPROPYL-5-METHYLPYRIMIDINE'>4XS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5c1w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c1w OCA], [https://pdbe.org/5c1w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5c1w RCSB], [https://www.ebi.ac.uk/pdbsum/5c1w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5c1w ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref> | |||
==See Also== | |||
*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]] | |||
== References == | |||
[[Category: | <references/> | ||
[[Category: Yan | __TOC__ | ||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Yan Y]] | |||
Latest revision as of 12:18, 6 March 2024
PDE10 complexed with 4,6-dichloro-2-cyclopropyl-5-methyl-pyrimidine
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