5c2u: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
m Protected "5c2u" [edit=sysop:move=sysop]
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
 
(6 intermediate revisions by the same user not shown)
Line 1: Line 1:
'''Unreleased structure'''


The entry 5c2u is ON HOLD  until Paper Publication
==Ferredoxin-like domain of nucleoporin Nup54 bound to a nanobody==
<StructureSection load='5c2u' size='340' side='right'caption='[[5c2u]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5c2u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Camelus_dromedarius Camelus dromedarius] and [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C2U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5C2U FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5c2u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c2u OCA], [https://pdbe.org/5c2u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5c2u RCSB], [https://www.ebi.ac.uk/pdbsum/5c2u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5c2u ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/K9ZTJ6_XENLA K9ZTJ6_XENLA]
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Nuclear pore complexes (NPCs) conduct nucleocytoplasmic transport and gain transport selectivity through nucleoporin FG domains. Here, we report a structural analysis of the FG Nup62*58*54 complex, which is a crucial component of the transport system. It comprises a approximately 13 nm long trimerization interface with an unusual 2W3F coil, a canonical heterotrimeric coiled coil, and a kink that enforces a compact six-helix bundle. Nup54 also contains a ferredoxin-like domain. We further identified a heterotrimeric Nup93-binding module for NPC anchorage. The quaternary structure alternations in the Nup62 complex, which were previously proposed to trigger a general NPC-gating, are incompatible with the trimer structure. We suggest that the highly elongated Nup62 complex projects barrier-forming FG-repeats far into the central NPC channel, supporting a barrier that guards the entire cross-section.


Authors: Chug, H., Trakhanov, S., Huelsmann, B.B., Pleiner, T., Goerlich, D.
Crystal structure of the metazoan Nup62*Nup58*Nup54 nucleoporin complex.,Chug H, Trakhanov S, Hulsmann BB, Pleiner T, Gorlich D Science. 2015 Aug 20. pii: aac7420. PMID:26292704<ref>PMID:26292704</ref>


Description: Ferredoxin-like domain of nucleoporin Nup54 bound to a nanobody
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
[[Category: Goerlich, D]]
<div class="pdbe-citations 5c2u" style="background-color:#fffaf0;"></div>
[[Category: Chug, H]]
 
[[Category: Huelsmann, B.B]]
==See Also==
[[Category: Trakhanov, S]]
*[[Nucleoporin 3D structures|Nucleoporin 3D structures]]
[[Category: Pleiner, T]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Camelus dromedarius]]
[[Category: Large Structures]]
[[Category: Xenopus laevis]]
[[Category: Chug H]]
[[Category: Gorlich D]]
[[Category: Hulsmann BB]]
[[Category: Pleiner T]]
[[Category: Trakhanov S]]
Retrieved from "https://proteopedia.org/5c2u"