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New page: left|200px {{Structure |PDB= 3cfl |SIZE=350|CAPTION= <scene name='initialview01'>3cfl</scene>, resolution 2.25Å |SITE= <scene name='pdbsite=AC1:Nag+Binding+Site+...
 
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[[Image:3cfl.jpg|left|200px]]


{{Structure
==Crystal structure of the complex formed between C-lobe of bovine lactoferrin and 5-chloro-6'-methyl-3-[4-(methylsulfonyl)phenyl]-2,3'-bipyridine at 2.25 A resolution==
|PDB= 3cfl |SIZE=350|CAPTION= <scene name='initialview01'>3cfl</scene>, resolution 2.25&Aring;
<StructureSection load='3cfl' size='340' side='right'caption='[[3cfl]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
|SITE= <scene name='pdbsite=AC1:Nag+Binding+Site+For+Residue+A+1'>AC1</scene>, <scene name='pdbsite=AC2:Nag+Binding+Site+For+Residue+A+2'>AC2</scene>, <scene name='pdbsite=AC3:Nag+Binding+Site+For+Residue+A+687'>AC3</scene>, <scene name='pdbsite=AC4:Nag+Binding+Site+For+Residue+A+688'>AC4</scene>, <scene name='pdbsite=AC5:Nag+Binding+Site+For+Residue+A+689'>AC5</scene>, <scene name='pdbsite=AC6:Nag+Binding+Site+For+Residue+A+690'>AC6</scene>, <scene name='pdbsite=AC7:Fe+Binding+Site+For+Residue+A+691'>AC7</scene>, <scene name='pdbsite=AC8:Co3+Binding+Site+For+Residue+A+692'>AC8</scene>, <scene name='pdbsite=AC9:Zn+Binding+Site+For+Residue+A+3'>AC9</scene>, <scene name='pdbsite=BC1:Zn+Binding+Site+For+Residue+A+4'>BC1</scene>, <scene name='pdbsite=BC2:So4+Binding+Site+For+Residue+A+5'>BC2</scene> and <scene name='pdbsite=BC3:5ch+Binding+Site+For+Residue+A+693'>BC3</scene>
== Structural highlights ==
|LIGAND= <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> and <scene name='pdbligand=5CH:'>5CH</scene>
<table><tr><td colspan='2'>[[3cfl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CFL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CFL FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
|GENE=  
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5CH:5-CHLORO-6-METHYL-3-[4-(METHYLSULFONYL)PHENYL]-2,3-BIPYRIDINE'>5CH</scene>, <scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cfl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cfl OCA], [https://pdbe.org/3cfl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cfl RCSB], [https://www.ebi.ac.uk/pdbsum/3cfl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cfl ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TRFL_BOVIN TRFL_BOVIN] Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref>  Lactotransferrin has antimicrobial activity. The most effective inhibitory activity was seen against E.coli and P.aeruginosa.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref>  Lactoferricin B is an antimicrobial peptide. Inhibits the growth of Gram-negative and Gram-positive bacteria.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref>  The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cf/3cfl_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cfl ConSurf].
<div style="clear:both"></div>


'''Crystal structure of the complex formed between C-lobe of bovine lactoferrin and 5-chloro-6'-methyl-3-[4-(methylsulfonyl)phenyl]-2,3'-bipyridine at 2.25 A resolution'''
==See Also==
 
*[[Lactoferrin|Lactoferrin]]
 
== References ==
==About this Structure==
<references/>
3CFL is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CFL OCA].
__TOC__
</StructureSection>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Kaur, P.]]
[[Category: Kaur P]]
[[Category: Mir, R.]]
[[Category: Mir R]]
[[Category: Sharma, S.]]
[[Category: Sharma S]]
[[Category: Singh, N.]]
[[Category: Singh N]]
[[Category: Singh, T P.]]
[[Category: Singh TP]]
[[Category: Vikram, G.]]
[[Category: Vikram G]]
[[Category: 5CH]]
[[Category: CO3]]
[[Category: FE]]
[[Category: SO4]]
[[Category: ZN]]
[[Category: antibiotic]]
[[Category: antimicrobial]]
[[Category: c-lobe]]
[[Category: complex]]
[[Category: crystal structure]]
[[Category: etoricoxib]]
[[Category: glycoprotein]]
[[Category: hydrolase]]
[[Category: ion transport]]
[[Category: iron]]
[[Category: iron transport]]
[[Category: metal binding protein]]
[[Category: metal-binding]]
[[Category: protease]]
[[Category: secreted]]
[[Category: serine protease]]
[[Category: transport]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 19:03:53 2008''

Latest revision as of 01:40, 21 November 2024

Crystal structure of the complex formed between C-lobe of bovine lactoferrin and 5-chloro-6'-methyl-3-[4-(methylsulfonyl)phenyl]-2,3'-bipyridine at 2.25 A resolution

3cfl, resolution 2.25Å

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