Variable lymphocyte receptor: Difference between revisions

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<StructureSection load='g3a' size='450' side='right' scene='Variable_Lymphocyte_Receptors/3g3a_biological_unit/3' caption='Variable lymphocyte receptor of lamprey (grey) bound to a protein antigen (green) ([[3g3a]]), resolution 2.20&Aring;'>
<StructureSection load='' size='350' side='right' scene='45/456531/Cv/1' caption='Variable lymphocyte receptor of lamprey (grey) bound to a protein antigen (green) ([[3g3a]]), resolution 2.20&Aring;'>
'''Variable lymphocyte receptors''' (VLRs) are [[leucine-rich repeat]] (LRR) family proteins that mediate adaptive immune responses in the jawless vertebrates, lampreys and hagfish. <ref>PMID: 17192264</ref>
'''Variable lymphocyte receptors''' (VLRs) are [[leucine-rich repeat]] (LRR) family proteins that mediate adaptive immune responses in the jawless vertebrates, lampreys and hagfish. <ref>PMID: 17192264</ref>
[[Image:3g3a biol unitsurf.png|370px|right|thumb| [[Lamprey Variable Lymphocyte Receptor]] in complex with a protein antigen ([[3g3a]])]]


<scene name='45/456531/Cv/3'>Leucines highlighted in magenta</scene>.
[[Image:3g3a biol unitsurf.png|370px|left|thumb| [[Lamprey Variable Lymphocyte Receptor]] in complex with a protein antigen ([[3g3a]])]]
{{Clear}}


==See Also==
==See Also==
*[[Lamprey Variable Lymphocyte Receptor]]
*[[leucine-rich repeat|Leucine-rich Repeat Proteins]]
*[[leucine-rich repeat|Leucine-rich Repeat Proteins]]
*[[Antibody]]
*[[Antibody]]
*[[Forkhead box protein]]
*[[Forkhead box protein]]
==3D structures of variable lymphocyte receptor==
==3D structures of variable lymphocyte receptor==
[[Variable lymphocyte receptor 3D structures]]
</StructureSection>


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|
*Variable lymphocyte receptor
**[[3m19]], [[3g39]], [[2r9u]], [[3wo9]], [[4k5u]], [[4k79]] - mlVLR ectodomain – marine lamprey<br />
**[[3m18]], [[3g3a]] – mlVLR ectodomain + lysozyme<br />
**[[3g3b]] - mlVLR ectodomain (mutant) + lysozyme<br />
**[[3e6j]] - mlVLR ectodomain + trisaccharide<br />
**[[2o6q]], [[2o6r]], [[2o6s]] – IhVLR leucine-rich repeat – inshore hagfish<br />
**[[3twi]] – VLR B antigen-binding domain + BCLA protein – ''Bacillus anthracis''<br />
*Variable lymphocyte receptor chimera
**[[2z62]], [[2z63]], [[2z66]] – IhVLR/hTLR4<br />
**[[4qxe]] – IhVLR/G-protein coupled receptor<br />
**[[4qxe]] – IhVLR/G-protein coupled receptor + r-spondin<br />
**[[3ul7]], [[3ul8]], [[3ul9]] – IhVLR/hTLR4 (mutant)<br />
**[[3ula]] – IhVLR/hTLR4 (mutant) + eritoran<br />
**[[2z80]], [[2z81]], [[2z82]], [[3a78]], [[3a7c]] – IhVLR/hTLR2<br />
**[[2z65]] – IhVLR/hTLR4 + lymphocyte antigen 96<br />
**[[2z7x]] – IhVLR/hTLR1 + IhVLR/hTLR2 + tri-acylated lipopeptide<br />
**[[3a79]] - IhVLR/hTLR2 + IhVLR/hTLR6 + tri-acylated lipopeptide<br />
**[[3v44]], [[3v47]] - VLR/TLR5B – zebra fish<br />
**[[4arn]], [[4arr]] - DmVLRB/TLR – ''Drosophila melanogaster''<br />
**[[4bv4]] - DmVLRB/TLR + spaetzle<br />
**[[4j4l]] - VLRB/internalin + interleukin-6 – ''Listeria monocytogenes''<br />
}}
Articles in Proteopedia concerning Variable lymphocyte receptors include:
Articles in Proteopedia concerning Variable lymphocyte receptors include:
*[[Lamprey Variable Lymphocyte Receptor]]
*[[Lamprey Variable Lymphocyte Receptor]]

Latest revision as of 08:40, 25 March 2020

Variable lymphocyte receptor of lamprey (grey) bound to a protein antigen (green) (3g3a), resolution 2.20Å

Drag the structure with the mouse to rotate

Articles in Proteopedia concerning Variable lymphocyte receptors include:

Additional Literature

  1. Bajoghli B, Guo P, Aghaallaei N, Hirano M, Strohmeier C, McCurley N, Bockman DE, Schorpp M, Cooper MD, Boehm T. A thymus candidate in lampreys. Nature. 2011 Feb 3;470(7332):90-4. PMID:21293377 doi:10.1038/nature09655
  2. Herrin BR, Cooper MD. Alternative adaptive immunity in jawless vertebrates. J Immunol. 2010 Aug 1;185(3):1367-74. PMID:20660361 doi:10.4049/jimmunol.0903128
  3. Mariuzza RA, Velikovsky CA, Deng L, Xu G, Pancer Z. Structural insights into the evolution of the adaptive immune system: the variable lymphocyte receptors of jawless vertebrates. Biol Chem. 2010 Jul;391(7):753-60. PMID:20482318 doi:10.1515/BC.2010.091
  4. Velikovsky CA, Deng L, Tasumi S, Iyer LM, Kerzic MC, Aravind L, Pancer Z, Mariuzza RA. Structure of a lamprey variable lymphocyte receptor in complex with a protein antigen. Nat Struct Mol Biol. 2009 Jul;16(7):725-30. Epub 2009 Jun 21. PMID:19543291 doi:10.1038/nsmb.1619
  5. Herrin BR, Cooper MD. Alternative adaptive immunity in jawless vertebrates. J Immunol. 2010 Aug 1;185(3):1367-74. PMID:20660361 doi:10.4049/jimmunol.0903128
  6. Herrin BR, Alder MN, Roux KH, Sina C, Ehrhardt GR, Boydston JA, Turnbough CL Jr, Cooper MD. Structure and specificity of lamprey monoclonal antibodies. Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):2040-5. Epub 2008 Jan 31. PMID:18238899 doi:10.1073/pnas.0711619105
  7. Han BW, Herrin BR, Cooper MD, Wilson IA. Antigen recognition by variable lymphocyte receptors. Science. 2008 Sep 26;321(5897):1834-7. PMID:18818359 doi:321/5897/1834

See Lamprey Variable Lymphocyte Receptor for details.

References

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman, Alexander Berchansky

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