Symporter: Difference between revisions

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<StructureSection load='4d2d' size='340' side='right' caption='Proton:oligopeptide symporter complex with tripeptide (PDB code [[4tpj]])' scene=''>
<StructureSection load='' size='350' side='right' caption='Dipeptide: H+ symporter (green) complex with dipeptide (cyan), lipid and phosphate (PDB code [[4d2c]])' scene='70/705726/Initial/2'>
Symporter (Symp) is a cotransporter membrane protein which transports two or more different molecules across the plasma membrane in the same direction.
 
== Function ==
== Function ==
'''Symporter''' (Symp) is a co-transporter membrane protein which transports two or more different molecules across the plasma membrane in the same direction<ref>PMID:12588808</ref>.


== Disease ==
== Disease ==
 
Mutations in sodium/iodide symporter cause iodide transport defects<ref>PMID:10403177</ref>.
== Relevance ==


== Structural highlights ==
== Structural highlights ==
 
Dipeptide: <scene name='70/705726/Cv/5'>H symporter binds the dipeptide</scene> between its N- and C-terminal bundles<ref>PMID:24916388</ref>.
</StructureSection>


== 3D Structures of symporter ==
== 3D Structures of symporter ==
[[Symporter 3D structures]]


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
</StructureSection>
{{#tree:id=OrganizedByTopic|openlevels=0|
 
*D-xylose-proton symporter
 
**[[4ja4]], [[4qiq]] – EcSymp – ''Escherichia coli''<BR />
**[[4ja3]] – EcSymp (mutant) <BR />
**[[4gby]] – EcSymp + xylose <BR />
**[[4gbz]], [[4gc0]] – EcSymp + glucose derivative<BR />
 
*Di-or tripeptide:H+ symporter
 
**[[4ja4]], [[4xni]], [[4d2b]], [[4aps]] – StSymp – ''Streptococcus thermophilus''<BR />
**[[4d2d]] – StSymp + tripeptide<BR />
**[[4d2c]] – StSymp + dipeptide<BR />
 
*Proton:oligopeptide symporter
 
**[[4lep]], [[4tph]] – SoSymp – ''Shewanella oneidensis''<BR />
**[[4tpg]], [[4tpj]] – SoSymp + tripeptide<BR />
 
*Sodium/bile acid symporter
 
**[[4n7w]] – YfSymp – ''Yersinia frederiksenii''<BR />
**[[4n7x]] – YfSymp (mutant) <BR />
 
*L-fucose-proton symporter
 
**[[3o7q]] – EcSymp <BR />
**[[3o7p]] – EcSymp (mutant)<BR />
 
*Sodium/glucose symporter


**[[2xq2]] – VpSymp (mutant) – ''Vibrio parahaemolyticus''<BR />
**[[3dh4]] – VpSymp + galactose <BR />
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
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