Symporter: Difference between revisions

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<StructureSection load='4d2d' size='340' side='right' caption='Di-or tripeptide:H+ symporter (grey) complex with tripeptide (green), lipid and phosphate (PDB code [[4d2d]])' scene=''>
<StructureSection load='' size='350' side='right' caption='Dipeptide: H+ symporter (green) complex with dipeptide (cyan), lipid and phosphate (PDB code [[4d2c]])' scene='70/705726/Initial/2'>
Symporter (Symp) is a cotransporter membrane protein which transports two or more different molecules across the plasma membrane in the same direction.
 
== Function ==
== Function ==
'''Symporter''' (Symp) is a co-transporter membrane protein which transports two or more different molecules across the plasma membrane in the same direction<ref>PMID:12588808</ref>.


== Disease ==
== Disease ==
 
Mutations in sodium/iodide symporter cause iodide transport defects<ref>PMID:10403177</ref>.
== Relevance ==


== Structural highlights ==
== Structural highlights ==
 
Dipeptide: <scene name='70/705726/Cv/5'>H symporter binds the dipeptide</scene> between its N- and C-terminal bundles<ref>PMID:24916388</ref>.
</StructureSection>


== 3D Structures of symporter ==
== 3D Structures of symporter ==
[[Symporter 3D structures]]


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
</StructureSection>
{{#tree:id=OrganizedByTopic|openlevels=0|
 
*D-xylose-proton symporter
 
**[[4ja4]], [[4qiq]] – EcSymp – ''Escherichia coli''<BR />
**[[4ja3]] – EcSymp (mutant) <BR />
**[[4gby]] – EcSymp + xylose <BR />
**[[4gbz]], [[4gc0]] – EcSymp + glucose derivative<BR />
 
*Di-or tripeptide:H+ symporter
 
**[[4ja4]], [[4xni]], [[4d2b]], [[4aps]] – StSymp – ''Streptococcus thermophilus''<BR />
**[[4d2d]] – StSymp + tripeptide<BR />
**[[4d2c]] – StSymp + dipeptide<BR />
 
*Proton:oligopeptide symporter
 
**[[4lep]], [[4tph]] – SoSymp – ''Shewanella oneidensis''<BR />
**[[4tpg]], [[4tpj]] – SoSymp + tripeptide<BR />
 
*Sodium/bile acid symporter
 
**[[4n7w]] – YfSymp – ''Yersinia frederiksenii''<BR />
**[[4n7x]] – YfSymp (mutant) <BR />
 
*L-fucose-proton symporter
 
**[[3o7q]] – EcSymp <BR />
**[[3o7p]] – EcSymp (mutant)<BR />
 
*Sodium/glucose symporter


**[[2xq2]] – VpSymp (mutant) – ''Vibrio parahaemolyticus''<BR />
**[[3dh4]] – VpSymp + galactose <BR />
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]

Latest revision as of 11:12, 15 November 2020

Dipeptide: H+ symporter (green) complex with dipeptide (cyan), lipid and phosphate (PDB code 4d2c)

Drag the structure with the mouse to rotate

References

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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