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[[Image:3ink.gif|left|200px]]


{{Structure
==UNRAVELING THE STRUCTURE OF INTERLEUKIN-2: REPLY==
|PDB= 3ink |SIZE=350|CAPTION= <scene name='initialview01'>3ink</scene>, resolution 2.5&Aring;
<StructureSection load='3ink' size='340' side='right'caption='[[3ink]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND=  
<table><tr><td colspan='2'>[[3ink]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3INK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3INK FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
|GENE=  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ink FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ink OCA], [https://pdbe.org/3ink PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ink RCSB], [https://www.ebi.ac.uk/pdbsum/3ink PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ink ProSAT]</span></td></tr>
}}
</table>
== Disease ==
[https://www.uniprot.org/uniprot/IL2_HUMAN IL2_HUMAN] Note=A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.
== Function ==
[https://www.uniprot.org/uniprot/IL2_HUMAN IL2_HUMAN] Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/in/3ink_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ink ConSurf].
<div style="clear:both"></div>


'''UNRAVELING THE STRUCTURE OF INTERLEUKIN-2: REPLY'''
==See Also==
 
*[[Interleukin 3D structures|Interleukin 3D structures]]
 
__TOC__
==Disease==
</StructureSection>
Known disease associated with this structure: Severe combined immunodeficiency due to IL2 deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147680 147680]]
 
==About this Structure==
3INK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3INK OCA].
 
==Reference==
Unraveling the structure of IL-2., Bazan JF, Science. 1992 Jul 17;257(5068):410-3. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1631562 1631562]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Brandhuber, B J.]]
[[Category: Brandhuber BJ]]
[[Category: Mckay, D B.]]
[[Category: Mckay DB]]
[[Category: cytokine]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 19:05:27 2008''
Retrieved from "https://proteopedia.org/3ink"