5c8h: Difference between revisions
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New page: '''Unreleased structure''' The entry 5c8h is ON HOLD Authors: Tempel, W., Xu, Z., Dong, A., Loppnau, P., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Conso... |
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==Crystal structure of ORC2 C-terminal domain== | |||
<StructureSection load='5c8h' size='340' side='right'caption='[[5c8h]], [[Resolution|resolution]] 2.01Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5c8h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C8H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5C8H FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.01Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5c8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c8h OCA], [https://pdbe.org/5c8h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5c8h RCSB], [https://www.ebi.ac.uk/pdbsum/5c8h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5c8h ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: Bountra | == Function == | ||
[[Category: | [https://www.uniprot.org/uniprot/ORC2_HUMAN ORC2_HUMAN] Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3. Stabilizes LRWD1, by protecting it from ubiquitin-mediated proteasomal degradation. Also stabilizes ORC3.<ref>PMID:22427655</ref> <ref>PMID:22935713</ref> | ||
[[Category: | == References == | ||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | |||
[[Category: Arrowsmith CH]] | |||
[[Category: Bountra C]] | |||
[[Category: Dong A]] | |||
[[Category: Edwards AM]] | |||
[[Category: Loppnau P]] | |||
[[Category: Min J]] | |||
[[Category: Tempel W]] | |||
[[Category: Xu C]] | |||
Latest revision as of 08:35, 27 September 2023
Crystal structure of ORC2 C-terminal domain
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