Haptoglobin receptor: Difference between revisions

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'''Haptoglobin receptor''' (IsdH) is part of the iron-regulated surface determinant system that captures heme from the host hemoproteins. IsdH binds haptoglobin (Hp) which removes hemoglobin (Hb) from the blood by forming Hp-Hb complex. IsdH contains multiple '''NEAT''' (Near Transporter) domains which bind proteins and heme. For more details see [[Molecular Playground/Hemoglobin-Haptoglobin Complex]].

== Function ==

'''Haptoglobin receptor''' or '''Iron-regulated surface determinant protein H''' (IsdH) is part of the iron-regulated surface determinant system that captures heme from the host hemoproteins. IsdH binds haptoglobin (Hp) which removes hemoglobin (Hb) from the blood by forming Hp-Hb complex. IsdH contains multiple '''NEAT''' (Near Transporter) domains which bind proteins and heme<ref>PMID:18451305</ref>. For more details see [[Molecular Playground/Hemoglobin-Haptoglobin Complex]].

=~~= Disease ==~~

*<scene name='70/706235/Cv/5'>IsdH NEAT-3 domain complex with heme-containing hemoglobin subunits α and β</scene>. (PDB code [[3szk]])

*<scene name='70/706235/Cv/6'>Heme binding in subunit α</scene>.

=~~= Relevance ==~~

*<scene name='70/706235/Cv/7'>Heme binding in subunit β</scene>.

~~== Structural highlights~~ ==

</StructureSection>

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{{#tree:id=OrganizedByTopic|openlevels=0|

*IsdH NEAT-1 domain

*IsdH NEAT-1 domain 86-229

**[[2h3k]] – SaIsdH NEAT-1 domain – ''Staphylococcus aureus'' - NMR

**[[3ovu]] – SaIsdH NEAT-1 domain + Hb α + α-Hb-stabilizing protein

**[[4wjg]] – SaIsdH NEAT-1 domain + Hb α+β + Hp + Hp-Hb receptor

**[[4wjg]] – SaIsdH NEAT-1 domain 92-406 + Hb α+β + Hp + Hp-Hb receptor

**[[3szk]] – SaIsdH NEAT-1 domain + Hb α+β

**[[3s48]] – SaIsdH NEAT-1 domain + Hb α

*IsdH NEAT-2 domain

*IsdH NEAT-2 domain 321-464

**[[4fc3]] – SaIsdH NEAT-2 domain + Hb α+β

*IsdH NEAT-3 domain

*IsdH NEAT-3 domain 539-664

**[[3vua]] – SaIsdH NEAT-3 domain

**[[2z6f]] – SaIsdH NEAT-3 domain + heme

**[[3qug]], [[3quh]], [[3vtm]] – SaIsdH NEAT-3 domain + porphyrin

**[[3szk]] – SaIsdH NEAT-3 domain + Hb α+β

**[[3s48]] – SaIsdH NEAT-3 domain + Hb α

*IsdH NEAT-2-3 domain

*IsdH NEAT-linker-3 domain 476-656

**[[7w81]] – SaIsdH NEAT-linker-3 domain + heme

**[[7xld]] – SaIsdH NEAT-linker-3 domain + nanobody

*IsdH NEAT-2-3 domain 326-660

**[[4ij2]], [[4xs0]] – SaIsdH NEAT-2-3 domain (mutant) + Hb α+β

*IsdH linker domain

*IsdH linker domain 467-543

**[[2lhr]] – SaIsdH linker domain - NMR

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== References ==

[[Category:Topic Page]]

Haptoglobin receptor: Difference between revisions

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+<StructureSection load='' size='400' side='right' caption='IsdH NEAT-3 domain (magenta) complex with heme-containing hemoglobin subunits α (green) and β (deepskyblue) (PDB code [[3szk]])' scene='70/706235/Cv/1' pspeed='8'>
-<StructureSection load='3szk' size='340' side='right' caption='IsdH NEAT-3 domain complex with hemoglobin subunits α,β (PDB code [[3szk]])' scene=''>
-'''Haptoglobin receptor''' (IsdH) is part of the iron-regulated surface determinant system that captures heme from the host hemoproteins.  IsdH binds haptoglobin (Hp) which removes hemoglobin (Hb) from the blood by forming Hp-Hb complex.  IsdH contains multiple '''NEAT''' (Near Transporter) domains which bind proteins and heme.  For more details see [[Molecular Playground/Hemoglobin-Haptoglobin Complex]].
 == Function ==
+'''Haptoglobin receptor''' or '''Iron-regulated surface determinant protein H''' (IsdH) is part of the iron-regulated surface determinant system that captures heme from the host hemoproteins.  IsdH binds haptoglobin (Hp) which removes hemoglobin (Hb) from the blood by forming Hp-Hb complex.  IsdH contains multiple '''NEAT''' (Near Transporter) domains which bind proteins and heme<ref>PMID:18451305</ref>.  For more details see [[Molecular Playground/Hemoglobin-Haptoglobin Complex]].
-== Disease ==
+*<scene name='70/706235/Cv/5'>IsdH NEAT-3 domain complex with heme-containing hemoglobin subunits α and β</scene>. (PDB code [[3szk]])
+*<scene name='70/706235/Cv/6'>Heme binding in subunit α</scene>.
-== Relevance ==
+*<scene name='70/706235/Cv/7'>Heme binding in subunit β</scene>.
-== Structural highlights ==
 </StructureSection>
@@ Line 18: / Line 12: @@
 {{#tree:id=OrganizedByTopic|openlevels=0|
-*IsdH NEAT-1 domain
+*IsdH NEAT-1 domain 86-229
 **[[2h3k]] – SaIsdH NEAT-1 domain – ''Staphylococcus aureus'' - NMR<BR />
 **[[3ovu]] – SaIsdH NEAT-1 domain + Hb α + α-Hb-stabilizing protein<BR />
-**[[4wjg]] – SaIsdH NEAT-1 domain + Hb α+β + Hp + Hp-Hb receptor<BR />
+**[[4wjg]] – SaIsdH NEAT-1 domain 92-406 + Hb α+β + Hp + Hp-Hb receptor<BR />
+**[[3szk]] – SaIsdH NEAT-1 domain + Hb α+β<BR />
+**[[3s48]] – SaIsdH NEAT-1 domain + Hb α<BR />
-*IsdH NEAT-2 domain
+*IsdH NEAT-2 domain 321-464
 **[[4fc3]] – SaIsdH NEAT-2 domain + Hb α+β<BR />
-*IsdH NEAT-3 domain
+*IsdH NEAT-3 domain 539-664
 **[[3vua]] – SaIsdH NEAT-3 domain <BR />
 **[[2z6f]] – SaIsdH NEAT-3 domain + heme<BR />
 **[[3qug]], [[3quh]], [[3vtm]] – SaIsdH NEAT-3 domain + porphyrin<BR />
-**[[3szk]] – SaIsdH NEAT-3 domain + Hb α+β<BR />
-**[[3s48]] – SaIsdH NEAT-3 domain + Hb α<BR />
-*IsdH NEAT-2-3 domain
+*IsdH NEAT-linker-3 domain 476-656
+**[[7w81]] – SaIsdH NEAT-linker-3 domain + heme<BR />
+**[[7xld]] – SaIsdH NEAT-linker-3 domain + nanobody<BR />
+*IsdH NEAT-2-3 domain 326-660
 **[[4ij2]], [[4xs0]] – SaIsdH NEAT-2-3 domain (mutant) + Hb α+β<BR />
-*IsdH linker domain
+*IsdH linker domain 467-543
 **[[2lhr]] – SaIsdH linker domain - NMR<BR />
@@ Line 48: / Line 47: @@
 == References ==
 <references/>
+[[Category:Topic Page]]