5ccl: Difference between revisions
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New page: '''Unreleased structure''' The entry 5ccl is ON HOLD Authors: Boriack-Sjodin, P.A. Description: Crystal structure of SMYD3 with SAM and oxindole compound [[Category: Unreleased Structu... |
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==Crystal structure of SMYD3 with SAM and oxindole compound== | |||
<StructureSection load='5ccl' size='340' side='right'caption='[[5ccl]], [[Resolution|resolution]] 1.50Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5ccl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CCL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CCL FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4ZW:2-OXIDANYLIDENE-N-PIPERIDIN-4-YL-1,3-DIHYDROINDOLE-5-CARBOXAMIDE'>4ZW</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ccl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ccl OCA], [https://pdbe.org/5ccl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ccl RCSB], [https://www.ebi.ac.uk/pdbsum/5ccl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ccl ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/SMYD3_HUMAN SMYD3_HUMAN] Histone methyltransferase. Specifically methylates 'Lys-4' and 'Lys-5' of histone H3, inducing di- and tri-methylation, but not monomethylation. Plays an important role in transcriptional activation as a member of an RNA polymerase complex. Binds DNA containing 5'-CCCTCC-3' or 5'-GAGGGG-3' sequences.<ref>PMID:15235609</ref> <ref>PMID:22419068</ref> | |||
==See Also== | |||
*[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]] | |||
== References == | |||
[[Category: | <references/> | ||
[[Category: Boriack-Sjodin | __TOC__ | ||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Boriack-Sjodin PA]] | |||
Latest revision as of 12:20, 6 March 2024
Crystal structure of SMYD3 with SAM and oxindole compound
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