2n4y: Difference between revisions
From Proteopedia
Jump to navigationJump to search
m Protected "2n4y" [edit=sysop:move=sysop] |
No edit summary |
||
| (5 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
The | ==Structure and possible function of a G-quadruplex in the long terminal repeat of the proviral HIV-1 genome== | ||
<StructureSection load='2n4y' size='340' side='right'caption='[[2n4y]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2n4y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N4Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N4Y FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n4y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n4y OCA], [https://pdbe.org/2n4y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n4y RCSB], [https://www.ebi.ac.uk/pdbsum/2n4y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n4y ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The long terminal repeat (LTR) of the proviral human immunodeficiency virus (HIV)-1 genome is integral to virus transcription and host cell infection. The guanine-rich U3 region within the LTR promoter, previously shown to form G-quadruplex structures, represents an attractive target to inhibit HIV transcription and replication. In this work, we report the structure of a biologically relevant G-quadruplex within the LTR promoter region of HIV-1. The guanine-rich sequence designated LTR-IV forms a well-defined structure in physiological cationic solution. The nuclear magnetic resonance (NMR) structure of this sequence reveals a parallel-stranded G-quadruplex containing a single-nucleotide thymine bulge, which participates in a conserved stacking interaction with a neighboring single-nucleotide adenine loop. Transcription analysis in a HIV-1 replication competent cell indicates that the LTR-IV region may act as a modulator of G-quadruplex formation in the LTR promoter. Consequently, the LTR-IV G-quadruplex structure presented within this work could represent a valuable target for the design of HIV therapeutics. | |||
Structure and possible function of a G-quadruplex in the long terminal repeat of the proviral HIV-1 genome.,De Nicola B, Lech CJ, Heddi B, Regmi S, Frasson I, Perrone R, Richter SN, Phan AT Nucleic Acids Res. 2016 Jun 13. pii: gkw432. PMID:27298260<ref>PMID:27298260</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
[[Category: Heddi | <div class="pdbe-citations 2n4y" style="background-color:#fffaf0;"></div> | ||
[[Category: Lech | == References == | ||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: Richter | [[Category: Large Structures]] | ||
[[Category: Synthetic construct]] | |||
[[Category: DeNicola B]] | |||
[[Category: Frasson I]] | |||
[[Category: Heddi B]] | |||
[[Category: Lech CJ]] | |||
[[Category: Perrone R]] | |||
[[Category: Phan AT]] | |||
[[Category: Regmi S]] | |||
[[Category: Richter SN]] | |||
Latest revision as of 06:15, 15 May 2024
Structure and possible function of a G-quadruplex in the long terminal repeat of the proviral HIV-1 genome
| ||||||||||||
