Profilin: Difference between revisions

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New page: <StructureSection load='2pbd' size='340' side='right' caption='Human profilin I complex with α-actin and VASP protein poly-Pro peptide (PDB code 2pbd)' scene=''> '''Profilin''' (PFN)...
 
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<StructureSection load='2pbd' size='340' side='right' caption='Human profilin I (green) complex with α-actin (grey),  VASP protein poly-Pro peptide (olive), ATP and Ca+2 ion (PDB code [[2pbd]])' scene=''>
<StructureSection load='2pbd' size='340' side='right' caption='Human profilin I complex with α-actin and VASP protein poly-Pro peptide (PDB code [[2pbd]])' scene=''>
'''Profilin''' (PFN) enhances actin growth by binding to monomeric actin, thus becoming profilactin.  PFN catalyzes the exchange of poorly polymerizing ADP-actin to readily polymerizing ATP-actin.  PFN binds to poly-L-proline, thus it recruits the actin monomers to proline-rich proteins like VASP, which enhance the growing of actin polymers.  PFN-I is expressed in most tissues while PFN-II is expressed in brain and kidney.  PFN was found in all eukaryotes.
 
== Function ==
== Function ==
'''Profilin''' (PFN) enhances actin growth by binding to monomeric actin, thus becoming profilactin.  PFN catalyzes the exchange of poorly polymerizing ADP-actin to readily polymerizing ATP-actin<ref>PMID:27307590</ref>.  PFN binds to poly-L-proline, thus it recruits the actin monomers to proline-rich proteins like VASP, which enhance the growing of actin polymers.  '''PFN-I''' is expressed in most tissues while '''PFN-II''' is expressed in brain and kidney.  PFN was found in all eukaryotes.


== Disease ==
== Disease ==


PFN from birch, peanut and other plants is a major allergen.
PFN from birch, peanut and other plants is a major allergen<ref>PMID:25123397</ref>.


== Relevance ==
== 3D Structures of profilin ==
 
[[Profilin 3D Structures]]
== Structural highlights ==


</StructureSection>
</StructureSection>


== 3D Structures of profilin ==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|
*Profilin I
**[[1fik]], [[1fil]], [[4x1l]] – hPFN – human <br />
**[[1pfl]] – hPFN - NMR  <br />
**[[4x25]], [[4x1m]] – hPFN (mutant)  <br />
**[[1pne]] – bPFN – bovine  <br />
**[[1cqa]] – PFN - birch  <br />
**[[3nul]], [[1a0k]] – PFN – ''Arabidopsis thaliana''  <br />
**[[1ypr]], [[1k0k]] – PFN - yeast  <br />
**[[3d9y]], [[3dav]] – PFN – fission yeast <br />
**[[1g5u]] – PFN – ''Hevea brasiliensis'' <br />
**[[2jkf]] – PfPFN – ''Plasmodium falciparum''  <br />
**[[4esp]] – PFN – peanut <br />
**[[4qwo]] – PFN – monkeypox virus <br />
**[[2prf]] – AcPFN – ''Acanthamoeba castellanii''  - NMR<br />
**[[1prq]] – AcPFN <br />
**[[3nec]] – PFN – ''Toxoplasma gondii''<br />
*Profilin I complex
**[[2btf]], [[3u4l]], [[3ub5]] – bPFN + β-actin  <br />
**[[1hlu]] – bPFN + β-actin  + ATP <br />
**[[2jkg]] – PfPFN + poly-Pro peptide  <br />
**[[1awi]], [[1cf0]], [[1cjf]] – hPFN + poly-Pro peptide  <br />
**[[2pav]], [[2pbd]], [[3chw]] – hPFN + α-actin + VASP poly-Pro peptide  <br />
*Profilin II
**[[1acf]], [[2acg]], [[1f2k]] – AcPFN  <br />
**[[1d1j]] – hPFN  <br />
**[[2vk3]] – PFN - rat <br />
**[[2v8c]] – mPFN + VASP poly-Pro peptide - mouse  <br />
**[[2v8f]] – mPFN + MDIA1 poly-Pro peptide  <br />
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]

Latest revision as of 10:43, 27 November 2019

Human profilin I (green) complex withα-actin (grey), VASP protein poly-Pro peptide (olive), ATP and Ca+2 ion (PDB code 2pbd)

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References

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel

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