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| <StructureSection load='2pbd' size='340' side='right' caption='Human profilin I (green) complex with α-actin (pale green), VASP protein poly-Pro peptide (olive), ATP (stick model) and Ca+2 ion (PDB code [[2pbd]])' scene=''> | | <StructureSection load='2pbd' size='340' side='right' caption='Human profilin I (green) complex with α-actin (grey), VASP protein poly-Pro peptide (olive), ATP and Ca+2 ion (PDB code [[2pbd]])' scene=''> |
| '''Profilin''' (PFN) enhances actin growth by binding to monomeric actin, thus becoming profilactin. PFN catalyzes the exchange of poorly polymerizing ADP-actin to readily polymerizing ATP-actin. PFN binds to poly-L-proline, thus it recruits the actin monomers to proline-rich proteins like VASP, which enhance the growing of actin polymers. PFN-I is expressed in most tissues while PFN-II is expressed in brain and kidney. PFN was found in all eukaryotes.
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| == Function == | | == Function == |
| | '''Profilin''' (PFN) enhances actin growth by binding to monomeric actin, thus becoming profilactin. PFN catalyzes the exchange of poorly polymerizing ADP-actin to readily polymerizing ATP-actin<ref>PMID:27307590</ref>. PFN binds to poly-L-proline, thus it recruits the actin monomers to proline-rich proteins like VASP, which enhance the growing of actin polymers. '''PFN-I''' is expressed in most tissues while '''PFN-II''' is expressed in brain and kidney. PFN was found in all eukaryotes. |
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| == Disease == | | == Disease == |
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| PFN from birch, peanut and other plants is a major allergen. | | PFN from birch, peanut and other plants is a major allergen<ref>PMID:25123397</ref>. |
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| == Relevance == | | == 3D Structures of profilin == |
| | | [[Profilin 3D Structures]] |
| == Structural highlights ==
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| </StructureSection> | | </StructureSection> |
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| == 3D Structures of profilin ==
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| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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| {{#tree:id=OrganizedByTopic|openlevels=0|
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| *Profilin I
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| **[[1fik]], [[1fil]], [[4x1l]] – hPFN – human <br />
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| **[[1pfl]] – hPFN - NMR <br />
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| **[[4x25]], [[4x1m]] – hPFN (mutant) <br />
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| **[[1pne]] – bPFN – bovine <br />
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| **[[1cqa]] – PFN - birch <br />
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| **[[3nul]], [[1a0k]] – PFN – ''Arabidopsis thaliana'' <br />
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| **[[1ypr]], [[1k0k]] – PFN - yeast <br />
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| **[[3d9y]], [[3dav]] – PFN – fission yeast <br />
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| **[[1g5u]] – PFN – ''Hevea brasiliensis'' <br />
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| **[[2jkf]] – PfPFN – ''Plasmodium falciparum'' <br />
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| **[[4esp]] – PFN – peanut <br />
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| **[[4qwo]] – PFN – monkeypox virus <br />
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| **[[2prf]] – AcPFN – ''Acanthamoeba castellanii'' - NMR<br />
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| **[[1prq]] – AcPFN <br />
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| **[[3nec]] – PFN – ''Toxoplasma gondii''<br />
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| *Profilin I complex
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| **[[2btf]], [[3u4l]], [[3ub5]] – bPFN + β-actin <br />
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| **[[1hlu]] – bPFN + β-actin + ATP <br />
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| **[[2jkg]] – PfPFN + poly-Pro peptide <br />
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| **[[1awi]], [[1cf0]], [[1cjf]] – hPFN + poly-Pro peptide <br />
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| **[[2pav]], [[2pbd]], [[3chw]] – hPFN + α-actin + VASP poly-Pro peptide + ATP <br />
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| *Profilin II
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| **[[1acf]], [[2acg]], [[1f2k]] – AcPFN <br />
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| **[[1d1j]] – hPFN <br />
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| **[[2vk3]] – PFN - rat <br />
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| **[[2v8c]] – mPFN + VASP poly-Pro peptide - mouse <br />
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| **[[2v8f]] – mPFN + MDIA1 poly-Pro peptide <br />
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| }}
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| == References == | | == References == |
| <references/> | | <references/> |
| | [[Category:Topic Page]] |
