5cfo: Difference between revisions

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New page: '''Unreleased structure''' The entry 5cfo is ON HOLD Authors: Kranzusch, P.J., Wilson, S.C., Lee, A.S.Y., Berger, J.M., Doudna, J.A., Vance, R.E. Description: [[Category: Unreleased S...
 
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'''Unreleased structure'''


The entry 5cfo is ON HOLD
==Crystal structure of anemone STING (Nematostella vectensis) in apo 'rotated' open conformation==
<StructureSection load='5cfo' size='340' side='right'caption='[[5cfo]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5cfo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Nematostella_vectensis Nematostella vectensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CFO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CFO FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.102&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cfo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cfo OCA], [https://pdbe.org/5cfo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cfo RCSB], [https://www.ebi.ac.uk/pdbsum/5cfo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cfo ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/STING_NEMVE STING_NEMVE] Sensor of cytosolic DNA from bacteria and viruses that promotes autophagy (PubMed:30842662). Acts by recognizing and binding cyclic GMP-AMP (cGAMP), a messenger produced by CGAS in response to DNA in the cytosol (PubMed:26300263, PubMed:30842662). Following cGAMP-binding, promotes the formation of autophagosomes, leading to target cytosolic DNA for degradation by the lysosome (PubMed:30842662). Exhibits guanine base-specific ligand recognition. Binds 3'-3'linked cGAMP, 2'-3' linked cGAMP and 3'-3' linked c-di-GMP with much greater affinity as compared to 3'-3' linked c-di-AMP (PubMed:26300263). Lacks the C-terminal tail (CTT) found in mammalian orthologs which is essential for interferon signaling (PubMed:26300263).<ref>PMID:26300263</ref> <ref>PMID:30842662</ref>


Authors: Kranzusch, P.J., Wilson, S.C., Lee, A.S.Y., Berger, J.M., Doudna, J.A., Vance, R.E.
==See Also==
 
*[[Stimulator of interferon genes protein|Stimulator of interferon genes protein]]
Description:  
*[[Stimulator of interferon genes protein 3D structures|Stimulator of interferon genes protein 3D structures]]
[[Category: Unreleased Structures]]
== References ==
[[Category: Lee, A.S.Y]]
<references/>
[[Category: Kranzusch, P.J]]
__TOC__
[[Category: Vance, R.E]]
</StructureSection>
[[Category: Wilson, S.C]]
[[Category: Large Structures]]
[[Category: Berger, J.M]]
[[Category: Nematostella vectensis]]
[[Category: Doudna, J.A]]
[[Category: Berger JM]]
[[Category: Doudna JA]]
[[Category: Kranzusch PJ]]
[[Category: Lee ASY]]
[[Category: Vance RE]]
[[Category: Wilson SC]]
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