4y21: Difference between revisions
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==Crystal Structure of Munc13-1 MUN domain== | ==Crystal Structure of Munc13-1 MUN domain== | ||
<StructureSection load='4y21' size='340' side='right' caption='[[4y21]], [[Resolution|resolution]] 2.90Å' scene=''> | <StructureSection load='4y21' size='340' side='right'caption='[[4y21]], [[Resolution|resolution]] 2.90Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4y21]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y21 OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[4y21]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y21 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Y21 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4y21 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y21 OCA], [https://pdbe.org/4y21 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4y21 RCSB], [https://www.ebi.ac.uk/pdbsum/4y21 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4y21 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/UN13A_RAT UN13A_RAT] Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in most excitatory/glutamatergic but not inhibitory/GABA-mediated synapses. Also involved in secretory granule priming in insulin secretion.<ref>PMID:9697857</ref> <ref>PMID:11343654</ref> <ref>PMID:11792326</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 4y21" style="background-color:#fffaf0;"></div> | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Kang | [[Category: Large Structures]] | ||
[[Category: Ma | [[Category: Rattus norvegicus]] | ||
[[Category: Rizo | [[Category: Kang LJ]] | ||
[[Category: Sheng | [[Category: Ma C]] | ||
[[Category: Wang | [[Category: Rizo J]] | ||
[[Category: Wu | [[Category: Sheng Y]] | ||
[[Category: Xu | [[Category: Wang S]] | ||
[[Category: Yang | [[Category: Wu LJ]] | ||
[[Category: Zhang | [[Category: Xu T]] | ||
[[Category: Zhang | [[Category: Yang XY]] | ||
[[Category: Zou | [[Category: Zhang M]] | ||
[[Category: Zhang RG]] | |||
[[Category: Zou WJ]] | |||
Latest revision as of 15:33, 8 November 2023
Crystal Structure of Munc13-1 MUN domain
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