5civ: Difference between revisions
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New page: '''Unreleased structure''' The entry 5civ is ON HOLD Authors: Taylor, J.T., Matthews, S.J. Description: Sibling Lethal Factor Precursor -DfsB Category: Unreleased Structures [[Cate... |
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==Sibling Lethal Factor Precursor - DfsB== | |||
<StructureSection load='5civ' size='340' side='right'caption='[[5civ]], [[Resolution|resolution]] 1.38Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5civ]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Paenibacillus_dendritiformis Paenibacillus dendritiformis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CIV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CIV FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.384Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5civ FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5civ OCA], [https://pdbe.org/5civ PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5civ RCSB], [https://www.ebi.ac.uk/pdbsum/5civ PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5civ ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/D0EVD3_9BACL D0EVD3_9BACL] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Bacteria have developed a variety of mechanisms for surviving harsh environmental conditions, nutrient stress and overpopulation. Paenibacillus dendritiformis produces a lethal protein (Slf) that is able to induce cell death in neighbouring colonies and a phenotypic switch in more distant ones. Slf is derived from the secreted precursor protein, DfsB, after proteolytic processing. Here, we present new crystal structures of DfsB homologues from a variety of bacterial species and a surprising version present in the yeast Saccharomyces cerevisiae. Adopting a four-helix bundle decorated with a further three short helices within intervening loops, DfsB belongs to a non-enzymatic class of the DinB fold. The structure suggests that the biologically active Slf fragment may possess a C-terminal helix rich in basic and aromatic residues that suggest a functional mechanism akin to that for cationic antimicrobial peptides. | |||
Structures of the DfsB Protein Family Suggest a Cationic, Helical Sibling Lethal Factor Peptide.,Taylor JD, Taylor G, Hare SA, Matthews SJ J Mol Biol. 2016 Jan 21. pii: S0022-2836(16)00032-2. doi:, 10.1016/j.jmb.2016.01.013. PMID:26804569<ref>PMID:26804569</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
[[Category: Matthews | <div class="pdbe-citations 5civ" style="background-color:#fffaf0;"></div> | ||
[[Category: Taylor | == References == | ||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Paenibacillus dendritiformis]] | |||
[[Category: Matthews SJ]] | |||
[[Category: Taylor JD]] | |||
Latest revision as of 08:36, 9 October 2024
Sibling Lethal Factor Precursor - DfsB
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