5cjp: Difference between revisions

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New page: '''Unreleased structure''' The entry 5cjp is ON HOLD Authors: Worthylake, D.K., Boyapati, V.K., LeCour Jr, L. Description: X-ray structure of an IQGAP2 fragment bound to two molecules ...
 
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'''Unreleased structure'''


The entry 5cjp is ON HOLD
==The Structural Basis for Cdc42-Induced Dimerization of IQGAPs==
 
<StructureSection load='5cjp' size='340' side='right'caption='[[5cjp]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
Authors: Worthylake, D.K., Boyapati, V.K., LeCour Jr, L.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5cjp]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CJP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CJP FirstGlance]. <br>
Description: X-ray structure of an IQGAP2 fragment bound to two molecules of Cdc42
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
[[Category: Boyapati, V.K]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cjp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cjp OCA], [https://pdbe.org/5cjp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cjp RCSB], [https://www.ebi.ac.uk/pdbsum/5cjp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cjp ProSAT]</span></td></tr>
[[Category: Lecour Jr, L]]
</table>
[[Category: Worthylake, D.K]]
== Function ==
[https://www.uniprot.org/uniprot/CDC42_HUMAN CDC42_HUMAN] Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration.<ref>PMID:14978216</ref> <ref>PMID:15642749</ref> <ref>PMID:17038317</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Boyapati VK]]
[[Category: LeCour Jr L]]
[[Category: Worthylake DK]]
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