5cmr: Difference between revisions
From Proteopedia
Jump to navigationJump to search
m Protected "5cmr" [edit=sysop:move=sysop] |
No edit summary |
||
| (6 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
The | ==Crystal Structure of Linker-Mediated Zn-bound Human H-Ferritin variant 122H-delta C-star== | ||
<StructureSection load='5cmr' size='340' side='right'caption='[[5cmr]], [[Resolution|resolution]] 3.79Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5cmr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CMR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CMR FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.792Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BYD:N,N-DIHYDROXYBENZENE-1,4-DICARBOXAMIDE'>BYD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cmr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cmr OCA], [https://pdbe.org/5cmr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cmr RCSB], [https://www.ebi.ac.uk/pdbsum/5cmr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cmr ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/FRIH_HUMAN FRIH_HUMAN] Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
We describe here the construction of a three-dimensional, porous, crystalline framework formed by spherical protein nodes that assemble into a prescribed lattice arrangement through metal-organic linker-directed interactions. The octahedral iron storage en-zyme, ferritin, was engineered in its C3 symmetric pores with tripodal Zn coordination sites. Dynamic light scat-tering and crystallographic studies established that this Zn-ferritin construct could robustly self-assemble into the desired bcc-type crystals upon coordination of a ditopic linker bearing hydroxamic acid functional groups. This system represents the first example of a ternary protein-metal-organic crystalline framework whose formation is fully dependent on each of its three components. | |||
A Metal Organic Framework with Spherical Protein Nodes: Rational Chemical Design of 3D Protein Crystals.,Sontz PA, Bailey JB, Ahn S, Tezcan FA J Am Chem Soc. 2015 Aug 25. PMID:26305584<ref>PMID:26305584</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
[[Category: | <div class="pdbe-citations 5cmr" style="background-color:#fffaf0;"></div> | ||
[[Category: | |||
[[Category: | ==See Also== | ||
[[Category: | *[[Ferritin 3D structures|Ferritin 3D structures]] | ||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Ahn S]] | |||
[[Category: Bailey JB]] | |||
[[Category: Sontz PA]] | |||
[[Category: Tezcan FA]] | |||
