TNF receptor-associated factor: Difference between revisions

Latest revision as of 09:00, 19 August 2024

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Human TRAF2 TRAF domain (green) complex with TNFR type 1 associated death domain protein TRADD (deepskyblue) (PDB code 1f3v)

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Function

TNF receptor-associated factor (TRAF) are signal transducers and are involved in regulation of apoptosis, inflammation and antiviral response. There are 7 known TRAF proteins. All TRAF proteins share a C-terminal homology region named TRAF domain which can bind the cytoplasmic domain of receptors and other TRAF proteins^[1].

TRAF1 is the only TRAF which does not have N-terminal RING and zinc finger motifs.
TRAF2, TRAF5 and TRAF6 mediate activation of NF-κB and JNK.
TRAF3 mediates some innate immune receptor signals and regulates some post-translational modifications^[2].
TRAF4 is a binding partner of glycoproteins in platelets^[3].

Structural highlights

The interaction of TRAF2 with the adaptor protein TRADD is bipartite with one part containing mainly hydrophobic interactions while the second part contains mainly polar interactions^[4]. Hydrophobic, Polar

3D Structures of TNF receptor-associated factor

TNF receptor-associated factor 3D structures

↑ Bradley JR, Pober JS. Tumor necrosis factor receptor-associated factors (TRAFs). Oncogene. 2001 Oct 1;20(44):6482-91. PMID:11607847 doi:https://dx.doi.org/10.1038/sj.onc.1204788
↑ Hildebrand JM, Yi Z, Buchta CM, Poovassery J, Stunz LL, Bishop GA. Roles of tumor necrosis factor receptor associated factor 3 (TRAF3) and TRAF5 in immune cell functions. Immunol Rev. 2011 Nov;244(1):55-74. doi: 10.1111/j.1600-065X.2011.01055.x. PMID:22017431 doi:https://dx.doi.org/10.1111/j.1600-065X.2011.01055.x
↑ Arthur JF, Shen Y, Gardiner EE, Coleman L, Murphy D, Kenny D, Andrews RK, Berndt MC. TNF receptor-associated factor 4 (TRAF4) is a novel binding partner of glycoprotein Ib and glycoprotein VI in human platelets. J Thromb Haemost. 2011 Jan;9(1):163-72. doi: 10.1111/j.1538-7836.2010.04091.x. PMID:20946164 doi:https://dx.doi.org/10.1111/j.1538-7836.2010.04091.x
↑ Park YC, Ye H, Hsia C, Segal D, Rich RL, Liou HC, Myszka DG, Wu H. A novel mechanism of TRAF signaling revealed by structural and functional analyses of the TRADD-TRAF2 interaction. Cell. 2000 Jun 23;101(7):777-87. PMID:10892748

References

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

[1] Bradley JR, Pober JS. Tumor necrosis factor receptor-associated factors (TRAFs). Oncogene. 2001 Oct 1;20(44):6482-91. PMID:11607847 doi:https://dx.doi.org/10.1038/sj.onc.1204788

[2] Hildebrand JM, Yi Z, Buchta CM, Poovassery J, Stunz LL, Bishop GA. Roles of tumor necrosis factor receptor associated factor 3 (TRAF3) and TRAF5 in immune cell functions. Immunol Rev. 2011 Nov;244(1):55-74. doi: 10.1111/j.1600-065X.2011.01055.x. PMID:22017431 doi:https://dx.doi.org/10.1111/j.1600-065X.2011.01055.x

[3] Arthur JF, Shen Y, Gardiner EE, Coleman L, Murphy D, Kenny D, Andrews RK, Berndt MC. TNF receptor-associated factor 4 (TRAF4) is a novel binding partner of glycoprotein Ib and glycoprotein VI in human platelets. J Thromb Haemost. 2011 Jan;9(1):163-72. doi: 10.1111/j.1538-7836.2010.04091.x. PMID:20946164 doi:https://dx.doi.org/10.1111/j.1538-7836.2010.04091.x

[4] Park YC, Ye H, Hsia C, Segal D, Rich RL, Liou HC, Myszka DG, Wu H. A novel mechanism of TRAF signaling revealed by structural and functional analyses of the TRADD-TRAF2 interaction. Cell. 2000 Jun 23;101(7):777-87. PMID:10892748

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@@ Line 1: / Line 1: @@
+<StructureSection load='' size='350' side='right' caption='Human TRAF2 TRAF domain (green) complex with TNFR type 1 associated death domain protein TRADD (deepskyblue) (PDB code [[1f3v]])' scene='70/708054/Cv/1'>
-<StructureSection load='1d01' size='340' side='right' caption='Human TRAF2 TRAF domain complex with CD30 peptide (PDB code [[1d01]])' scene=''>
+__TOC__
-'''TNF receptor-associated factor''' (TRAF) are signal transducers and are involved in regulation of apoptosis, inflammation and antiviral response.  There are 7 known TRAF proteins.  All TRAF proteins share a C-terminal homology region named TRAF domain which can bind the cytoplasmic domain of receptors and other TRAF proteins.  TRAF2-6 have N-terminal RING and zinc finger motifs.  TRAF2, TRAF5 and TRAF6 mediate activation of NF-κB and JNK.
 == Function ==
+'''TNF receptor-associated factor''' (TRAF) are signal transducers and are involved in regulation of apoptosis, inflammation and antiviral response.  There are 7 known TRAF proteins.  All TRAF proteins share a C-terminal homology region named TRAF domain which can bind the cytoplasmic domain of receptors and other TRAF proteins<ref>PMID:11607847</ref>.
-== Disease ==
+*'''TRAF1''' is the only TRAF which does not have N-terminal RING and zinc finger motifs.
+*'''TRAF2, TRAF5 and TRAF6''' mediate activation of NF-κB and JNK.
-== Relevance ==
+*'''TRAF3''' mediates some innate immune receptor signals and regulates some post-translational modifications<ref>PMID:22017431</ref>.
+*'''TRAF4''' is a binding partner of glycoproteins in platelets<ref>PMID:20946164</ref>.
 == Structural highlights ==
+The interaction of TRAF2 with the adaptor protein TRADD is <scene name='70/708054/Cv/4'>bipartite with one part containing mainly hydrophobic interactions while the second part contains mainly polar interactions</scene><ref>PMID:10892748</ref>. {{Template:ColorKey_Hydrophobic}},  {{Template:ColorKey_Polar}}
+== 3D Structures of TNF receptor-associated factor ==
+[[TNF receptor-associated factor 3D structures]]
 </StructureSection>
-== 3D Structures of TNF receptor-associated factor ==
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-{{#tree:id=OrganizedByTopic|openlevels=0|
-*TRAF1
-**[[3m0d]] – hTRAF1 residues 266-329 + hTRAF2 + cIAP2 - human<br />
-*TRAF2
-**[[1ca4]] – hTRAF2 TRAF domain <br />
-**[[3knv]] – hTRAF2 RING+zinc finger 1 domains <br />
-**[[3m06]] – hTRAF2 residues 266-329 <br />
-*TRAF2 complex with peptide
-**[[1ca9]] – hTRAF2 TRAF domain + TNF-R2 peptide<br />
-**[[1qsc]], [[1d00]], [[1czz]] – hTRAF2 TRAF domain + CD40 receptor peptide<br />
-**[[1d01]] – hTRAF2 TRAF domain + CD30 peptide<br />
-**[[1czy]] – hTRAF2 TRAF domain + latent membrane protein peptide<br />
-**[[1d0a]] – hTRAF2 TRAF domain + OX40L receptor peptide<br />
-**[[1d0j]] – hTRAF2 TRAF domain + 4-1BB ligand receptor peptide<br />
-**[[1f3v]] – hTRAF2 TRAF domain + TRADD N terminal<br />
-**[[3m0a]] – hTRAF2 residues 266-329 + cIAP2<br />
-*TRAF6
-**[[1lb4]] – hTRAF6 TRAF domain <br />
-**[[2jmd]], [[2eci]] – hTRAF6 RING domain - NMR<br />
-**[[3hcs]] – hTRAF6 RING+zinc finger 1-3 domains <br />
-*TRAF6 complex with peptide
-**[[1lb5]] – hTRAF6 TRAF domain + RANK peptide<br />
-**[[1lb6]] – hTRAF6 TRAF domain + CD40 antigen peptide<br />
-**[[3hct]], [[3hcu]] – hTRAF6 RING+zinc finger 1 domains + ubiquitin-conjugating enzyme E2<br />
-}}
 == References ==
 <references/>
+[[Category:Topic Page]]

TNF receptor-associated factor: Difference between revisions

Latest revision as of 09:00, 19 August 2024

Contents

Function

Structural highlights

3D Structures of TNF receptor-associated factor

References

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