5c4u: Difference between revisions
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==Identification of a Novel Allosteric Binding Site for RORgt Inhibitors== | |||
<StructureSection load='5c4u' size='340' side='right'caption='[[5c4u]], [[Resolution|resolution]] 2.08Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5c4u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C4U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5C4U FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.08Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4Y7:4-{1-[2-CHLORO-6-(TRIFLUOROMETHYL)BENZOYL]-1H-PYRAZOLO[4,3-B]PYRIDIN-3-YL}-5-FLUORO-2-HYDROXYBENZOIC+ACID'>4Y7</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5c4u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c4u OCA], [https://pdbe.org/5c4u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5c4u RCSB], [https://www.ebi.ac.uk/pdbsum/5c4u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5c4u ProSAT]</span></td></tr> | ||
[[Category: Parthasarathy | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/RORG_HUMAN RORG_HUMAN] Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Parthasarathy G]] | |||
[[Category: Soisson S]] | |||
Latest revision as of 12:18, 6 March 2024
Identification of a Novel Allosteric Binding Site for RORgt Inhibitors
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