5coi: Difference between revisions
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==Crystal Structure of the first bromodomain of human BRD4 in complex with benzo[cd]indol-2(1H)-one ligand== | |||
<StructureSection load='5coi' size='340' side='right'caption='[[5coi]], [[Resolution|resolution]] 1.62Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5coi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5COI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5COI FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.62Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=55K:1-({[(1-ETHYL-2-OXO-1,2-DIHYDROBENZO[CD]INDOL-6-YL)SULFONYL]AMINO}METHYL)CYCLOPENTANECARBOXYLIC+ACID'>55K</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5coi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5coi OCA], [https://pdbe.org/5coi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5coi RCSB], [https://www.ebi.ac.uk/pdbsum/5coi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5coi ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). | |||
==See Also== | |||
*[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]] | |||
== References == | |||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: Liu | </StructureSection> | ||
[[Category: Song | [[Category: Homo sapiens]] | ||
[[Category: Xue | [[Category: Large Structures]] | ||
[[Category: Liu Z]] | |||
[[Category: Song M]] | |||
[[Category: Xu Y]] | |||
[[Category: Xue X]] | |||
[[Category: Zhang Y]] | |||
Latest revision as of 09:09, 20 March 2024
Crystal Structure of the first bromodomain of human BRD4 in complex with benzo[cd]indol-2(1H)-one ligand
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